CAS: 19057-67-1; (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-2-(((4S,5'R,6Ar,6Bs,8As,8Br,9S,10R,11As,12As,12Bs)-5',6A,8A,9-Tetramethyl-1,3,3',4,4',5,5',6,6A,6B,6',7,8,8A,8B,9,11A,12,12A,12B-Icosahydrospiro[naphtho[2',1':4,5]Indeno[2,1-B]Furan-10,2'-Pyran]-4-yl)Oxy)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-Methyltetrahydro-2H-Pyran-3,4,5-Triol

上下游产品

2)>-4)>-β-D-glucopyranosidediosgenin 3-O-α-L-rhamnopyranosyl(1*2)-β-D-glucopyranosyl(1*4)-β-D-glucopyranoside 4)-[α-L-rhamnopyranosyl-(1->2)]-β-D-glucopyranoside(3β,25R)-spirost-5-en-3-ol-3-O-α-L-arabinofuranosyl-(1-4)-[α-L-rhamnopyranosyl-(1-2)]-β-D-glucopyranoside 2)-O-β-D-glucopyranoside>(25R)-26-O-β-D-glucopyranosyl-22-O-methylfurost-5-ene-3β,22ξ,26-triol 3-O-2)-O-β-D-glucopyranoside dioscin diosgenin trillin

📜Diosgenyl 2-O-(2,3,4-Tri-O-Acetyl-α-L-Rhamnopyranosyl)-4,6-O-Benzylidene-3-O-Pivaloyl-β-D-Glucopyranoside置于溶剂黄146,甲醇,Sodium Methylate体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,以41%的收率获得重楼皂苷e
参考文献:Synthesis Of Novel Spirostanic Saponins And Their Cytotoxic Activity
标题:Synthesis Of Novel Spirostanic Saponins And Their Cytotoxic Activity
摘要:This Study Was Carried Out To Assess The Cytotoxicity Of Several New Synthetic Steroidal Saponins Against The Human Myeloid Leukemia Cell Lines (Hl-60 And U937) And Against Human Melanoma Cells (Sk-Mel-1). Several Diosgenyl Glycosides Analyzed Showed Strong Cell Growth Inhibition Which Was Associated With Alterations In Cell Cycle Progression And Induction Of Apoptosis. Studies Of Cytochrome C Release And Caspase-9 Activation Suggest A Main Role Of The Intrinsic Pathway Of Apoptosis In The Mechanism Of Cytotoxicity Caused By This Kind Of Compounds. (C) 2007 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2007.10.089

专利信息

专利号:US-9718850-B2
优先权日:2008-04-08
标题:Triterpene saponins, methods of synthesis and uses thereof
发明人：GIN DAVID; ADAMS MICHELLE; DENG KAI; LIVINGSTON PHILIP; RAGUPATHI GOVINDASWAMI; CHEA ERIC; FERNANDEZ-TEJADA ALBERTO; NORDSTROEM LARS ULRIK; Walkowicz William; GARDNER JEFFREY; TAN DEREK
权利人:MEMORIAL SLOAN-KETTERING INST FOR CANCER RES
摘要:The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

专利号:US-2017283450-A1
优先权日:2008-04-08
标题 :Triterpene saponins, methods of synthesis and uses thereof

专利号:KR-102453184-B1
优先权日:2008-04-08
标 题:Triterpene saponins, methods of synthesis, and uses thereof

专利号:US-2013011421-A1
优先权日:2008-04-08
标题 :Triterpene saponins, methods of synthesis, and uses thereof

专利号:US-8283456-B2
优先权日:2008-04-08
标 题 :Triterpene saponins, methods of synthesis, and uses thereof

专利号:AU-2017258850-B2
优先权日:2008-04-08
标题 :Triterpene saponins, methods of synthesis, and uses thereof