CAS: 1544300-84-6; L-Threonine, L-Histidyl-L-Seryl-L-Glutaminylglycyl-L-Threonyl-L-Phenylalanyl-L-Threonyl-L-Seryl-L-α-Aspartyl-L-Tyrosyl-L-Seryl-L-Lysyl-L-Tyrosyl-L-Leucyl-L-α-Aspartyl-2-Methylalanyl-L-Alanyl-L-Arginyl-L-Alanyl-L-α-Glutamyl-L-α-Glutamyl-L-Phenylalanyl-L-Valyl-L-Lysyl-L-Tryptophyl-L-Leucyl-L-α-Glutamyl-L-Seryl-
- 英文名称L-Threonine, L-Histidyl-L-Seryl-L-Glutaminylglycyl-L-Threonyl-L-Phenylalanyl-L-Threonyl-L-Seryl-L-α-Aspartyl-L-Tyrosyl-L-Seryl-L-Lysyl-L-Tyrosyl-L-Leucyl-L-α-Aspartyl-2-Methylalanyl-L-Alanyl-L-Arginyl-L-Alanyl-L-α-Glutamyl-L-α-Glutamyl-L-Phenylalanyl-L-Valyl-L-Lysyl-L-Tryptophyl-L-Leucyl-L-α-Glutamyl-L-Seryl-
- IUPAC名称L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-2-methylalanyl-L-alanyl-L-arginyl-L-alanyl-L-alpha-glutamyl-L-alpha
- CAS编号1544300-84-6
- 分子式:C152H222N38O50分子量:3381.66
- 产品CID: 761734
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主要参考文献
1: Li S, Hu Y, Tan X, Wang D, Hu J, Zou P, Wang L. Evaluating dasiglucagon as a treatment option for hypoglycemia in diabetes. Expert Opin Pharmacother. 2020 Aug;21(11):1311-1318. doi: 10.1080/14656566.2020.1747432. Epub 2020 Apr 8. 19(10):97. doi: 10.1007/s11892-019-1216-4.
3: Castle JR, Elander M. Long-Term Safety and Tolerability of Dasiglucagon, a Stable-in-Solution Glucagon Analogue. Diabetes Technol Ther. 2019 Feb;21(2):94-96. doi: 10.1089/dia.2018.0363. 21(3):601-610. doi: 10.1111/dom.13562. Epub 2018 Nov 28.
5: Hövelmann U, Bysted BV, Mouritzen U, Macchi F, Lamers D, Kronshage B, Møller DV, Heise T. Pharmacokinetic and Pharmacodynamic Characteristics of Dasiglucagon, a Novel Soluble and Stable Glucagon Analog. Diabetes Care. 2018 Mar;41(3):531-537. doi: 10.2337/dc17-1402. Epub 2017 Dec 22. 53(7):405-413. doi: 10.1358/dot.2017.53.7.2669148.
合成参考文献
参考文献:10.2337/dc21-2252
摘要:Nielsen CK, Øhrstrøm CC, Kielgast UL, Hansen DL, Hartmann B, Holst JJ, Lund A, Vilsbøll T, Knop FK. Dasiglucagon Effectively Mitigates Postbariatric Postprandial Hypoglycemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. Diabetes Care. 2022 Jun 02;45(6):1476–81. doi: 10.2337/dc21-2252.
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