专利号:US-12421534-B2 优先权日:2021-11-10 标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs 发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.
专利号:US-2012226018-A1 优先权日:2009-11-16 标 题:Process for the Synthesis of Ac-Arg-Cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2 发明人:DONG ZHENG XIN 权利人:DONG ZHENG XIN; IPSEN PHARMA SAS 摘要:The present invention relates to a novel process for the synthesis of the melanocortin analog, Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH 2 , using solution-phase peptide chemistry.
专利号:US-9115179-B2 优先权日:2012-06-22 标题 :Synthesis of beta-turn peptidomimetic cyclic compounds 发明人:LAMA TERESA; PASCAL JEANICK 权利人:MIMETOGEN PHARMACEUTICALS INC 摘要:The present invention relates to methods of preparing β-turn cyclic peptidomimetic compounds and intermediates thereof. Particularly, the present invention relates to a process for the synthesis of β-turn cyclic peptidomimetic compounds of formula I: n nwhere R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , L 2 , X, Y and n are as defined in the specification.n n The present invention provides a more efficient route for preparing β-turn cyclic peptidomimetic compounds and intermediates thereof.
专利号:US-8202985-B2 优先权日:2005-10-31 标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H 权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.
专利号:US-7759471-B2 优先权日:2005-10-31 标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H 权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.
专利号:EP-0264802-B1 优先权日:1986-10-21 标 题:Synthesis of peptide-aminoalkyl amides and peptide hydrazides by the solid phase method 摘要:Compounds of the formula I in which A is hydrogen or an amino protective group, B is an amino acid residue, X is alkylene or aralkylene, Y<1>, Y<2>, Y<3> and Y<4> are identical or different and are hydrogen, methyl, methoxy or nitro, V is hydrogen or a carboxyl protective group, W is -[CH2]n- or -O-[CH2]n-, m is 0 or 1, n is 0 to 6 and p is 0 to 5, are prepared as described and used in the solid-phase synthesis.
摘要:J. F. Burke and N. W. Whitehouse, Biochem. Pharmacol. 14, 1039 (1965). 参考文献:10.1007/s10886-021-01324-4 摘要:Bohman B, Tan MMY, Flematti GR, Peakall R. Drakolide Structure-activity Relationships for Sexual Attraction of Zeleboria Wasp Pollinator. Journal of Chemical Ecology. 2022 Jan 31;48(3):323–36. doi: 10.1007/s10886-021-01324-4.