CAS: 107021-38-5; (2R,3R,4S,5R,6R)-2-((5-Bromo-4-Chloro-1H-Indol-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

上下游产品

1-乙酰基-5-溴-4-氯吲哚-3-乙酸酯 1-Acetyl-5-Bromo-4-Chloro-3-Indolyl Acetate 06/06/3030
5-溴-4-氯-3-吲哚-1-醋酸盐 1-Acetyl-5-Bromo-4-Chloro-3-Hydroxyindole 125328-76-9

📜1-乙酰基-5-溴-4-氯吲哚-3-乙酸酯置于三氟甲磺酸三甲基硅酯,硫酸,四丁基氟化铵,Sodium Methylate,溶剂黄146体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,化学反应 2.53H,反应生成5-溴-4-氯-3-吲哚基-Alpha-D-吡喃半乳糖苷
参考文献:作为显色糖苷酶底物的 1,2-Cis-Indoxyl 半乳糖苷的合成†
标题:作为显色糖苷酶底物的 1,2-Cis-Indoxyl 半乳糖苷的合成†
摘要:本研究首先使用环状酮吲哚受体和糖基三氯乙酰亚胺供体制备烯醇糖苷和 4,6-O-二叔丁基甲硅烷基保护的半乳糖基供体完成合成.目标化合物在 α-半乳糖苷酶存在下显示出酶活性.
Doi:10.1039/c9Ra05797H

专利信息

专利号:US-7255989-B1
优先权日:1999-11-29
标 题:Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds
发明人：JEANNIN PASCALE; PERNODET JEAN-LUC; GUERINEAU MICHEL; SIMONET PASCAL; COURTOIS SOPHIE; CAPPELLANO CAMELA; FRANCOU FRANCOIS; RAYNAL ALAIN; BALL MARIA; SEZONOV GUENNADI; TUPHILE KARINE; FROSTEGARD ASA
权利人:AVENTIS PHARMA SA
摘要:The invention concerns a method for preparing nucleic acids from an environment sample, more particularly a method for obtaining a library of nucleic acids from a sample. The invention also concerns nucleic acids of nucleic acid libraries obtained by said method their use in the synthesis of novel compounds, in particular novel compounds of therapeutic interest. The invent further concerns novel means used in the method for obtaining said nucleic acids, such as novel vectors and novel processes for preparing such vectors or recombinant host cells containing said nucleic acid. Finally, the invention concerns methods for detecting a nucleic acid of interest within a library of nucleic acids resulting from said method, and nucleic acids detected by said method and polypeptides encoded by said nucleic acids.

专利号:US-7608442-B2
优先权日:1999-02-01
标题:β1,3-galactosyltransferase polypeptides from the LOS locus of C. jejuni
发明人：GILBERT MICHEL; WAKARCHUK WARREN W
权利人:CA NAT RESEARCH COUNCIL
摘要:This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni . In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.

专利号:US-5912153-A
优先权日:1993-11-18
标 题 :(1,3) β-glucan synthase genes and inducible inhibition of fungal growth using the antisense constructs derived therefrom
发明人：SELITRENNIKOFF CLAUDE P; ENDERLIN CAROL S
摘要:A (1,3)β-glucan synthase mutant useful in the research and development of anti-fungal drugs. A key step in fungal wall assembly, hyphal growth and infection is the synthesis of (1,3)β-linked glucan. Because β-glucan is not made by humans, (1,3)β-glucan synthase is an attractive target for development of new antifungal antibiotics. A (1,3)β-glucan synthase gene has been cloned and the cDNA sequence and polypeptide amino acid sequence of the gene has been established.

专利号:US-2003170627-A1
优先权日:2000-11-27
标 题:cDNAs co-expressed with placental steroid synthesis genes
发明人：WALKER MICHAEL G; WONG SOPHIA LI-MING
摘要:The invention provides novel cDNAs that coexpress with known placental steroid synthesis genes. The invention also provides expression vectors, host cells, proteins encoded by the cDNAs and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of disorders associated with steroid-responsive tissues and with pregnancy.

专利号:US-7160711-B2
优先权日:2001-08-06
标题:Coryneform bacteria which produce chemical compounds I
发明人：BATHE BRIGITTE; KREUTZER CAROLINE; MOCKEL BETTINA; THIERBACH GEORG
权利人:DEGUSSA
摘要:The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.

专利号:US-5834182-A
优先权日:1994-06-06
标 题:Method for increasing transduction of cells by adeno-associated virus vectors
发明人：ALEXANDER IAN E; RUSSELL DAVID W; MILLER A DUSTY
权利人:HUTCHINSON FRED CANCER RES
摘要:This invention includes methods for increasing the efficiency of transduction of cells, including non-dividing cells, by recombinant AAV vectors. The methods utilize agents that alter certain aspects of DNA metabolism, more specifically, that affect DNA synthesis and/or affect repair, that impact on maintenance of chromosomal integrity, and/or that cause damage to the cellular DNA. Agents and vectors can now also be preselected and screened for transducing ability and/or transducing agents for their effect on DNA metabolism. These agents include tritiated nucleotides such as thymidine, gamma irradiation, UV irradiation, cis-platinum, etoposide, hydroxyurea and aphidicolin.