CAS: 98674-80-7; (4R)-2-Hydroxy-5,5-Dimethyl-4-Phenyl-1,3,2-Dioxaphosphinane 2-Oxide
该化合物是一种磷化合物,具有独特的结构特征,包括磷环系系统.该化合物由于存在多个立体中心,通常具有性能,能够影响其反应和与生物系统的互动.氢氧基化合物有助于其作为悬浮体或协调化学的潜力,而苯基组可能增强其在有机溶剂中的稳定性和溶性.此外,磷在结构中的存在表明磷在催化,材料科学等领域或作为有机合成的一种前体的潜在应用.具体的立体化学学(2R,4R)表明,该化合物与其立体异构体相比,可能具有独特的物理和化学特性,而这些特性对于其在各种应用中的功能至关重要.
- 英文名称(4R)-2-Hydroxy-5,5-Dimethyl-4-Phenyl-1,3,2-Dioxaphosphinane 2-Oxide
- 中文名称(4R)-2-羟基-5,5-二甲基-4-苯基-1,3,2-二噁磷己环 2-氧化物
- IUPAC名称(4R)-2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane 2-oxide
- 其它别名(R)-(-)-2-Hydroxy-5,5-Dimethyl-4-Phenyl-1,3,2-Dioxaphosphorinane 2-Oxide; (R)-(-)-5,5-Dimethyl-2-Hydroxy 4-Phenyl-1,3,2-Dioxaphos-Phorinane-2-Oxide; (2R,4R)-5,5-Dimethyl-2-Hydroxy-4-Phenyl-1,3,2-Dioxaphosphorinan 2-Oxide; (2R,4R)-2-Hydroxy-5,5-Dimethyl-4-Phenyl-1,3,2-Dioxaphosphorinan 2-Oxide; (R)-(-)-2-Hydroxy-5,5-Dimethyl-4-Phenyl- 1,3,2-Dioxaphosphorinane 2-Oxid ; (4R)-2-Hydroxy-5,5-Dimethyl-4-Phenyl-1,3,2-Dioxaphosphorinan 2-Oxide; (R)-(-)-2-Hydroxy-5,5-Dimethyl-4-Phenyl-1,3,2-Dioxaphosphorinane 2-Oxide, (2R,4R)-5,5-Dimethyl-2-Hydroxy-4-Phenyl-1,3,2-Dioxaphosphorinan 2-Oxide; (4R)-2-Hydroxy-5,5-Dimethyl-4-Phenyl-1,3,2-Dioxaphosphorinan 2-Oxide
- CAS编号98674-80-7
- MFCD编号:MFCD00044976
- EINECS号:628-971-1
- 分子式:C11H15O4P分子量:242.21
- 产品CID: 2027530
- 产品分类分析化学 → 分析试剂 → 常用分析试剂
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide 1-phenyl-2,2-dimethyl-1,3-propanediol benzaldehyde 2-chloro-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide (S)-(+)-1-phenyl-2,2-dimethyl-1,3-propanediol (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane (2S,4R)-5,5-Dimethyl-4-phenyl-[1,3,2]dioxaphosphinane 2-oxide合成工艺路线路线简述
📜5,5-Dimethyl-2-Hydroxy-4-Phenyl-1,3,2-Dioxaphosphorinane 2-Oxide 反应生成 (4R)-2-羟基-5,5-二甲基-4-苯基-1,3,2-二噁磷己环 2-氧化物
参考文献:The Design Of Resolving Agents. Chiral Cyclic Phosphoric Acids
标题:The Design Of Resolving Agents. Chiral Cyclic Phosphoric Acids
摘要:
DOI:10.1021/jo00223A018
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905399001-1,3-丙二醇
2906210000-苄醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11999741-B2
优先权日:2017-05-26
标 题:Process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
发明人：SVENSTRUP NIELS; ZHANG JUN; SUN JIKUI; CHEN YUYIN; KONG JIANSHE; MA RUJIAN; ZHANG JUNHUA; QIN LIANG; XIAO HUANMING; SUN JINXU; MENG XIAO; SUN FENGLAI; ZHU JINGYANG
权利人:CARDURION PHARMACEUTICALS INC
摘要:The present disclosure relates to processes for preparing 64(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7h-imidazo[1,5-a]pyrazin-8-one.
专利号:US-2025019381-A1
优先权日:2017-05-26
标题 :PROCESS FOR THE SYNTHESIS OF 6-((3S,4S)-4-METHYL-1-(PYRIMIDIN-2-YLMETHYL)PYRROLIDIN-3-YL)-3-(TETRAHYDROPYRAN-4-YL-7H-IMIDAZO[1,5-a]PYRAZIN-8-ONE
专利号:US-11370795-B2
优先权日:2017-05-26
标 题 :Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
专利号:US-2012053165-A1
优先权日:2009-03-03
标 题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
发明人：ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG
权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-2012202787-A1
优先权日:2009-10-20
标 题:Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators
发明人：AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN
权利人:AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
