CAS: 7559-04-8; 2-((3R,7R,11R)-3-Hydroxy-3,7,11,15-Tetramethylhexadecyl)-3,5,6-Trimethylcyclohexa-2,5-Diene-1,4-Dione

该化合物是二氯丙醇的衍生物,通常称为维生素E.该化合物的特征是其抗氧化特性,保护细胞部件免受氧化性损害.多氯丙酮是通过氧化异酚的氧化形成,导致含有与维生素E有关的某些生物活动的化合物.该化合物一般是黄到褐色固体,在有机溶剂中溶解,但在水中则较少.该化合物在各种生物化学过程中发挥作用,包括细胞信号和基因表达调节.该化合物的抗氧化性活动可归因于它能够捕捉自由基,从而有助于维护细胞健康.多氯丙酮对营养科学和药理学都有意义,因为它可能对健康和疾病预防产生影响,特别是在与氧化性压力有关的条件下.

结构式图片

相似化合物

40662-29-1 4584-63-8 719-22-2

上下游产品

CAS号59-02-9 维生素E油 | CAS号32466-45-8 (R,R,R)-α-t°Cop... | CAS号58-95-7 α-生育酚醋酸酯 | CAS号527-18-4 四甲基氢醌 | CAS号527-17-3 四甲基-1,4-苯醌 | CAS号103808-42-0 2,5-二甲氧基-3,4,6-... | CAS号13199-54-7 1,4-dimethoxy-2... | CAS号10191-41-0 DL-α-生育酚 | CAS号14745-36-9 2-(3-hydroxy-3,... | CAS号59-02-9 维生素E油

合成工艺路线路线简述

    📜Dl-α-生育酚,N-溴代丁二酰亚胺(Nbs) 反应生成 生育酚杂质11
    参考文献:Liebler,Daniel C.;Kaysen,Kathryn L.;Kennedy,Todd A.,Biochemistry,28,(1989) N5,C. 9777-9784
    标题:Liebler,Daniel C.;Kaysen,Kathryn L.;Kennedy,Todd A.,Biochemistry,28,(1989) N5,C. 9777-9784

    海关参考信息

    专利信息


    专利号:US-9950319-B2
    优先权日:2014-07-15
    标题:High exchange-capacity anion exchange resin with dual functional-groups and method of synthesis thereof
    发明人:WANG JINNAN; WANG YI; YANG XIN; CHENG CHENG; CHEN CHEN
    权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING UNIV YANCHENG ENVIRONMENTAL PROTECTION TECH AND ENGINEERING RESEARCH INST; NANJING UNIV YANCHENG ENVIRONMENTAL PROTECTION TECHNOLOGY AND ENGINEERING RESEARCH INSTITUTE
    摘要:The present disclosed are a high exchange-capacity anion exchange resin with dual functional-groups and method of synthesis thereof. The invention relates to the field of environmental function material synthesis and application. The resin is based on chloromethylated polystyrene-divinylbenzene polymer as matrix, and by primary amination and quaternization, yields an anion exchange resin with dual functional-groups having both a weak base anionic group and a strong base anionic group. The anion exchange resin not only has high adsorption capacity for water-born nitrate ions, but also can effectively squelch natural organic acids such as phytic acid in water, thus simultaneously removing nitrate ions and phytic acid organic matter from water. Therefore, the resin has a broad application potential in the fields of drinking water treatment, groundwater remediation, and advanced urban sewage treatment.

    专利号:US-5243072-A
    优先权日:1988-06-13
    标 题:Betaine group-containing polysaccharides with recurring anhydroglucose units, their synthesis and their use in cosmetic preparations
    发明人:GRUENING BURGHARD; HOFFMANN KLAUS; KOERNER GOETZ; KOLLMEIER HANS-JOACHIM
    权利人:GOLDSCHMIDT AG TH
    摘要:Betaine group-containing polysaccharides with recurring anhydroglucose units of the average, general formula are disclosed. In this formula the R1 groups are the same or different and represent methyl, in which n=2 or 3, m=0 to 10, p=0 to 10 and R2 is a hydrogen atom or the betaine group in which R3 and R4 are the same or different and represent an alkyl group with 1 to 4 carbon atoms and R5 is a divalent aliphatic hydrocarbon group with 1 to 10 carbon atoms, with the proviso that at least 0.5% of the R1 groups in the polysaccharide molecule represent the betaine group. Also disclosed is a method for the synthesis of these compounds and their use in cosmetic preparations, expecially for the care of the hair. In addition, novel compounds of the general formula are disclosed as intermediates in which the substituents R3, R4 and R5 have the above meaning.

    专利号:US-5124446-A
    优先权日:1988-06-13
    标题 :Betaine group-containing polysaccharides with recurring anhydroglucose units, their synthesis and their use in cosmetic preparations
    发明人:GRUENING BURGHARD; HOFFMANN KLAUS; KOERNER GOETZ; KOLLMEIER HANS-JOACHIM
    权利人:GOLDSCHMIDT AG TH
    摘要:Betaine group-containing polysaccharides with recurring anhydroglucose units of the average, general formula are disclosed. In this formula the R1 groups are the same or different and represent methyl, (CnH2nO)mR2 or in which n=2 or 3, m=0 to 10, p=0 to 10 and R2 is a hydrogen atom or the betaine group in which R3 and R4 are the same or different and represent an alkyl group with 1 to 4 carbon atoms and R5 is a divalent aliphatic hydrocarbon group with 1 to 10 carbon atoms, with the proviso that at least 0.5% of the R1 groups in the polysaccharide molecule represent the betaine group. Also disclosed is a method for the synthesis of these compounds and their use in cosmetic preparations, especially for the care of the hair. In addition, novel compounds of the general formula are disclosed as intermediates in which the substituents R3, R4 and R5 have the above meaning.

    专利号:US-5023246-A
    优先权日:1988-06-13
    标 题:Betaine group-containing derivatives of carboxymethylcellulose, their synthesis and their use in cosmetic preparations
    发明人:GRUENING BURGHARD; HOFFMANN KLAUS; KOERNER GOETZ; KOLLMEIER HANS-JOACHIM
    权利人:GOLDSCHMIDT AG TH
    摘要:Betain group-containing derivatives of carboxymethylcellulose are disclosed. They are characterized in that all or a portion of the carboxymethyl groups are or is replaced by groups of the general formula wherein R1 is hydrogen or methyl group, R2 is a divalent aliphatic hydrocarbon group with 2 to 5 carbon atoms, R3, R4 is an alkyl group with 1 to 4 carbon atoms, R5 is a divalent aliphatic hydrocarbon group with 1 to 10 carbon atoms, with the proviso that, on the average, at least 0.1 betaine groups are contained for each anhydroglucose unit of the polymeric molecule. Also, a method for the synthesis of these compounds and their use in cosmetic preparations, especially for the care of hair, are disclosed. In addition, novel derivatives of carboxymethylcellulose with tertiary amino groups are taught as intermediates. In these derivatives, all or a portion of these groups are or is replaced by groups of the general formula in which the substituents R1, R2, R3 and R4 have the above meaning, with the proviso that, on the average, at least 0.1 tertiary amino groups are contained per anhydroglucose unit of the polymeric molecule.

    专利号:US-2011263720-A1
    优先权日:2010-03-09
    标 题 :Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same
    发明人:PAISLEY STEVEN D; LEPREE JASON M; HAWI AMALE; ECKHOFF MICHAEL
    权利人:PENWEST PHARMACEUTICALS CO
    摘要:The present invention is directed to a method of synthesizing a compound of Formula I: n n n n n n n n n n the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4.

    专利号:CN-102884037-A
    优先权日:2010-03-09
    标题 :Synthesis of α-tocopherol derivatives, and methods of use thereof

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Opatíková M, Semchonok DA, Kopečný D, Ilík P, Pospíšil P, Ilíková I, Roudnický P, Zeljković SĆ, Tarkowski P, Kyrilis FL, Hamdi F, Kastritis PL, Kouřil R. Cryo-EM structure of a plant photosystem II supercomplex with light- harvesting protein Lhcb8 and α-tocopherol. Nat Plants. 2023 Aug;9(8):1359-1369. doi: 10.1038/s41477-023-01483-0. Epub 2023 Aug 7. 29(18):1550-1557. doi: 10.1097/WNR.0000000000001147. 10(1):461. doi: 10.1186/s13071-017-2402-3.
    4: Huang YP, Liu HX, Song JL, Wu JP, Yuan P, Qiu SX. [Chemical Constituents from Mitrasacme pygmaea]. Zhong Yao Cai. 2016 Feb;39(2):315-7. Chinese. 1817(3):389-94. doi: 10.1016/j.bbabio.2011.12.002. Epub 2011 Dec 13. 19(21):6483-91. doi: 10.1016/j.bmc.2011.08.050. Epub 2011 Aug 28. 69(11):2142-8. doi: 10.1016/j.phytochem.2008.05.008. Epub 2008 Jun 24. 55(4):607-18. doi: 10.1111/j.1365-313X.2008.03539.x. Epub 2008 Apr 30. 1777(2):154-62. doi: 10.1016/j.bbabio.2007.10.008. Epub 2007 Oct 25. 41(6):730-7. doi: 10.1080/10715760701324075.
    11: Pazos M, Sánchez L, Medina I. Alpha-tocopherol oxidation in fish muscle during chilling and frozen storage. J Agric Food Chem. 2005 May 18;53(10):4000-5. doi: 10.1021/jf047843k. 1056(1-2):257-62. 42(28):8501-5. doi: 10.1021/bi034036q. 456(1-3):133-9. doi: 10.1016/s0014-2999(02)02618-3. 39(5):494-500. Japanese. doi: 10.3143/geriatrics.39.494. 50(19):5458-62. doi: 10.1021/jf0202584. 301(1):128-35. doi: 10.1006/abio.2001.5486. 36(7):719-26. doi: 10.1007/s11745-001-0777-6. 47(3):150-7. doi: 10.1159/000052789. 49(3):1508-11. doi: 10.1021/jf001142f.

    合成参考文献


    摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
    参考文献:10.1016/j.ajog.2004.01.067|10.1016/s0002-9378(04)00152-8
    摘要:Palan PR, Woodall AL, Anderson PS, Mikhail MS. α-Tocopherol and α-tocopheryl quinone levels in cervical intraepithelial neoplasia and cervical cancer. American Journal of Obstetrics and Gynecology. 2004 May;190(5):1407–10. doi: 10.1016/j.ajog.2004.01.067.
    参考文献:10.1016/0006-2952(92)90440-t
    摘要:Hayashi T, Kanetoshi A, Nakamura M, Tamura M, Shirahama H. Reduction of alpha-tocopherolquinone to alpha-tocopherolhydroquinone in rat hepatocytes. Biochem Pharmacol. 1992 Aug 04;44(3):489–93. doi: 10.1016/0006-2952(92)90440-t.
    参考文献:10.1016/0891-5849(92)90069-s
    摘要:Murphy ME, Kolvenbach R, Aleksis M, Hansen R, Sies H. Antioxidant depletion in aortic crossclamping ischemia: increase of the plasma alpha-tocopheryl quinone/alpha-tocopherol ratio. Free Radic Biol Med. 1992;13(2):95–100. doi: 10.1016/0891-5849(92)90069-s.
    参考文献:10.1016/0021-9673(95)00532-3
    摘要:Takeda H, Shibuya T, Yanagawa K, Kanoh H, Takasaki M. Simultaneous determination of alpha-tocopherol and alpha-tocopherolquinone by high-performance liquid chromatography and coulometric detection in the redox mode. J Chromatogr A. 1996 Jan 26;722(1-2):287–94. doi: 10.1016/0021-9673(95)00532-3.
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