CAS: 7304-32-7; 2-Fluoro-5-Nitrobenzoic Acid

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CAS号445-29-4 邻氟苯甲酸 | CAS号95-52-3 邻氟甲苯 | CAS号7697-37-2 硝酸 | CAS号367-79-3 2-氟-5-硝基苯甲酸乙酯 | CAS号4036-83-3 2-吗啉-5-硝基苯甲酸 | CAS号220705-28-2 3-(1,3-benzoxaz... | CAS号84832-00-8 5-氨基-2-氟苄醇 | CAS号2965-22-2 2-氟-5-硝基苯甲酸甲酯 | CAS号616-79-5 2-氨基-5-硝基苯甲酸 | CAS号63878-73-9 2-氟-5-硝基苄醇 | CAS号130047-15-3 5-AMINO-2-FLUOR... | CAS号56741-34-5 2-氟-5-氨基苯甲酸甲酯 | CAS号56741-33-4 5-氨基-2-氟苯甲酸

邻氟苯甲酸置于硫酸,硝酸体系中,化学反应 0.75H,以88%的收率获得产物2-氟-5-硝基苯甲酸
参考文献:7-苯并恶唑-2-基和7-苯并噻唑-2-基-6-氟喹诺酮类化合物的合成
标题:7-苯并恶唑-2-基和7-苯并噻唑-2-基-6-氟喹诺酮类化合物的合成
摘要:氟喹诺酮类,7-苯并恶唑-2-基-1-乙基-6-氟-1,4-二氢-4-氧喹啉-3-羧酸和7-苯并噻唑-2-基-1-乙基-6-氟-合成了1,4-二氢-4-氧代喹啉-3-羧酸.这些化合物是通过使用gould-Jacobs途径制得的喹啉环系统获得的.通过5-氨基-2-氟苯甲酸与2-氨基苯酚或2-氨基硫代苯酚的环化脱水反应,可得到所需的苯胺,3-苯并恶唑-2-基-4-氟苯胺和3-苯并噻唑-2-基-4-氟苯胺.分别使用多磷酸.
DOI:10.1002/jhet.5570350610

专利信息

专利号:US-9115179-B2
优先权日:2012-06-22
标题 :Synthesis of beta-turn peptidomimetic cyclic compounds
发明人：LAMA TERESA; PASCAL JEANICK
权利人:MIMETOGEN PHARMACEUTICALS INC
摘要:The present invention relates to methods of preparing β-turn cyclic peptidomimetic compounds and intermediates thereof. Particularly, the present invention relates to a process for the synthesis of β-turn cyclic peptidomimetic compounds of formula I: n nwhere R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , L 2 , X, Y and n are as defined in the specification.n n The present invention provides a more efficient route for preparing β-turn cyclic peptidomimetic compounds and intermediates thereof.

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-12281179-B2
优先权日:2015-07-09
标 题 :Solution phase synthesis of β-turn peptidomimetic cyclic salts
发明人：ROCCHI SÉBASTIEN; DEVIN CHANTAL; TIAN WEI; BOHLIN MARTIN
权利人:MIMETOGEN PHARMACEUTICALS INC
摘要:The present disclosure relates to methods of preparing and crystallizing β-turn cyclic peptidomimetic salts of formula I:where R1, R2, R3, R4, R5, R6, R7, R8, R10, X, Y and n are as defined in the specification.The present disclosure provides a more efficient route for preparing a crystalline form of a β-turn cyclic peptidomimetic compounds and salts thereof.

专利号:US-2005261474-A1
优先权日:2004-05-20
标题:Method of support-based chemical synthesis
发明人：HOUGHTEN RICHARD A; YU YONGPING
权利人:MIXTURE SCIENCES INC
摘要:A method of synthesis on a solid phase support is disclosed that provides a cleaved product containing a protecting group that would have been cleaved by reaction with anhydrous HF wherein the support is volatilized during cleavage of the protected product from the support by reaction with diluted HF.

专利号:US-2023357318-A1
优先权日:2015-07-09
标题:Solution phase synthesis of beta-turn peptidomimetic cyclic salts

专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries