Ethoxycarbonyl 6-Bromohexanoate置于ammonium Hydroxide,(Etopo2)4体系中,用 氯仿,丙酮 作为反应溶剂,化学反应 7.0H,反应生成 6-溴己腈 参考文献:2,4,10-三氧杂正丁基酯二甲酸酯; Verwendung Zur Synthese Von Substieriertencarbonsäurenmit Hilfe Von Grignard-Reagenzien 标题:2,4,10-三氧杂正丁基酯二甲酸酯; Verwendung Zur Synthese Von Substieriertencarbonsäurenmit Hilfe Von Grignard-Reagenzien 摘要:具有2,4,10-三氧杂金刚烷结构作为羧基保护基的邻苯二甲酸酯; 格氏试剂在取代羧酸合成中的应用. DOI:10.1002/hlca.19830660741
专利号:US-12076715-B1 优先权日:2021-04-15 标 题:Synthesis and characterization of air-stable iron-based catalysts for Suzuki-Miyaura cross-coupling reactions of alkyl halides and aryl boronic esters 发明人:WONG ALEXANDER; BYERS JEFFERY 权利人:THE TRUSTEES OF BOSTON COLLEGE 摘要:This disclosure relates to novel catalysts for Suzuki-Miyaura cross-coupling reactions, the use thereof, and the methods of making the same.
专利号:RU-2418798-C2 优先权日:2005-08-31 标 题 :Synthesis methods and intermediate compounds during synthesis of stereoisomeric compounds, suitable for treating gastrointestinal disorders and central nervous system disorders
专利号:KR-101351454-B1 优先权日:2005-08-31 标题:Methods and synthesis of stereoisomer compounds useful for the treatment of gastrointestinal and central nervous system disorders
专利号:SU-1724013-A3 优先权日:1987-11-23 标 题 :Method for synthesis of pyridazine amine derivatives or theirs pharmaceutically acceptable acid salts
专利号:US-4554276-A 优先权日:1983-10-03 标题:2-Amino-5-hydroxy-4-methylpyrimidine derivatives 发明人:LAMATTINA JOHN L 权利人:PFIZER 摘要:Novel 2-amino-5-hydroxy-4-methylpyrimidines and substituted amino derivatives thereof useful as inhibitors of leukotriene synthesis for the treatment of pulmonary, inflammatory and cardiovascular diseases, cancer and psoriasis. In addition these compounds are cytoprotective and therefore useful in the treatment of peptic ulcers. A process for the preparation of such active compounds by ring rearrangement of 2-amino-5-acetyloxazole, pharmaceutical compositions containing the novel active compounds and compositions containing these compounds in combination with other anti-inflammatory agents or gastric anti-secretory agents.
专利号:WO-2008080988-A2 优先权日:2006-12-28 标题:Cyclopentanone derivatives, method of synthesis and uses thereof
参考标题:Ring-Closing Metathesis In The Synthesis Of Biologically Active Peptidomimetics Of Apicidin A 作者:Prashant H. Deshmukh,Carsten Schulz-Fademrecht,Panayiotis A. Procopiou,David A. Vigushin,R. Charles Coombes,Anthony G. M. Barrett |发布日期:2007.1.8 摘要:Macrocyclic Peptidomimetics Are Reported, Which Employ Iterative Peptide Coupling Followed By High Yielding Ring-Closing Metathesis (Rcm) As The Key Cyclization Step. The Target Macrocyclic Compounds Include Examples Containing A (2S)-Amino-8-Oxodecanoic Acid (Aoda) Residue As Analogues Of Apicidin A, A Known Potent Histone Deacetylase (Hdac) Inhibitor. These Showed Modest Levels Of Biological Activity
合成参考文献
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