CAS: 65373-52-6; Oxazole-2-Carbaldehyde

该化合物是一种环状有机化合物,在2位置用一个气态体组取代了氧化氮环,这种结构具有典型的甲状腺和芳香热循环的反活动性,使它在有机合成中成为多功能中间体.其富电子氧化氮环在核生殖替代和循环反应方面增强了其效用,而藻类功能允许进一步衍生,如凝聚或减少.该化合物在建立复杂的环状框架的制药和农用化学研究中特别有用.其稳定性在标准条件下和定义明确的再活动特征确保合成应用的一贯性能.

结构式图片

相似化合物

33036-67-8 130551-92-7 68776-60-3

欧盟法规

ECHA物质C&L通报

上下游产品

2-oxazolyl lithium N,N-dimethyl-formamide oxazol 4-morpholinecarboxaldehyde(1,3-oxazol-2-yl)methanol oxazol-2-yl(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanol 2-[2,6-dimethyl-4-[[(oxazol-2-ylmethyl)amino]methyl]phenoxy]-2-methylpropanoic acid ethyl ester

合成工艺路线路线简述

    📜N,N-二甲基甲酰胺置于正丁基锂,盐酸,水体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 2.0H,反应生成 恶唑-2-甲醛
    参考文献:Wo2007/34144
    标题:Wo2007/34144

    海关参考信息

    专利信息


    专利号:WO-2017089470-A1
    优先权日:2015-11-27
    标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases
    发明人:HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS
    权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg
    摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.

    专利号:US-2013338369-A1
    优先权日:2011-03-07
    标 题 :Process for the Synthesis of Aminobiphenylene
    发明人:HEINRICH MARKUS; PRATSCH GERALD
    权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
    摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

    专利号:WO-2022127640-A1
    优先权日:2020-12-16
    标题:Process for synthesis of furan-based diamines
    发明人:GUO RUIJING; PIRES RAUL; BEUCK SASKIA; LATORRE MARTINEZ IRENE CRISTINA; PAN XIANGCHENG; JIANG YUAN
    权利人:COVESTRO DEUTSCHLAND AG; GUO RUIJING
    摘要:The invention provides a process for the synthesis of furan-based diamines based on renewable resources.

    专利号:US-6225329-B1
    优先权日:1998-03-12
    标 题 :Modulators of protein tyrosine phosphatases (PTPases)
    发明人:RICHTER LUTZ STEFAN; ANDERSEN HENRIK SUNE; VAGNER JOSEF; JEPPESEN CLAUS BEKKER; MOELLER NIELS PETER HUNDAHL; BRANNER SVEN; SU JING; BAKIR FARID; JUDGE LUKE MILBURN
    权利人:NOVO NORDISK AS
    摘要:The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like, n wherein A, R 1 , R 2 , R 3 , R 4 , R 16 and R 17 are as defined in the specification. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

    专利号:US-2005119332-A1
    优先权日:1998-03-12
    标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
    发明人:JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
    摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

    专利号:WO-9946244-A1
    优先权日:1998-03-12
    标题 :Modulators of protein tyrosine phosphatases (ptpases)
    发明人:JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
    权利人:NOVO NORDISK AS; ONTOGEN CORP
    摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Boyd, G. V., Science of Synthesis, (2002) 11, 456.
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