CAS: 593-56-6; O-Methylhydroxylamine Hydrochloride

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58377-44-9 110220-55-8 6638-79-5

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CAS号67-62-9 O-甲基羟胺 | CAS号100-39-0 溴化苄 | CAS号87-42-3 6-氯嘌呤 | CAS号7647-01-0 盐酸 | CAS号7732-18-5 水 | CAS号2446-51-7 N-甲氧基苯甲酰胺 | CAS号1914-20-1 N-甲氧基邻苯二甲酰亚胺 | CAS号5904-50-7 N-methoxysuccinimide | CAS号112403-78-8 N-methoxy-2-phe... | CAS号3871-28-1 N-甲氧基氨基甲酸乙酯 | CAS号5780-66-5 2-吡嗪甲醛 | CAS号5470-70-2 6-甲基烟酸甲酯 | CAS号76-84-6 三苯基甲醇 | CAS号73962-45-5 N-trityl-O-meth... | CAS号148991-82-6 2-benzyl-N-meth... | CAS号143216-79-9 17-(methoxyamin... | CAS号23601-49-2 N-methoxy-3-phe... | CAS号24914-56-5 N-methoxy-2,4,6... | CAS号850363-67-6 5-溴-4-甲氧基-1H-吲唑

硫酸二甲酯置于盐酸,Sodium Meta Bi Sulfate,二氧化硫,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 3.0H,反应生成 甲氧基胺盐酸盐
参考文献:一种2-甲氧亚胺基-2-呋喃乙酸的合成方法
标题:一种2-甲氧亚胺基-2-呋喃乙酸的合成方法
摘要:本发明提供了一种2‑甲氧亚胺基‑2‑呋喃乙酸的合成方法.本发明采用甲氧胺盐酸盐的水溶液直接进行肟化反应,甲氧胺盐酸盐水溶液无需再经过加碱蒸馏得到甲氧胺水溶液后再参与缩合反应,既简化了甲氧胺的生产工艺,又减少了液碱的消耗及蒸甲氧胺所需能耗,还可以减少甲氧胺蒸馏过程挥发带来的损失.

专利信息

专利号:WO-2019202611-A1
优先权日:2018-04-21
标题:An improved process for the synthesis of ivabradine and its pharmaceutically acceptable salts
发明人：NANDEPU Venkateswara Rao; BOPPANA DURGA PRASAD
权利人:METROCHEM API PVT
摘要:: Disclosed herein is an improved process for the preparation of Ivabradine and pharmaceutically acceptable salts thereof. The invention more particularly disclosesthe synthesis of key intermediates viz.,(S)-N-[(4,5-dimethoxybenzocydobut-l-yl)-methyl]-N- (methyl)amine hydrochloride of Formula-II and 3-(3-Iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzapin-2-one of Formula-III, and its use in industrial synthesis of Ivabradine and pharmaceutically acceptable salts thereof.

专利号:US-2023339906-A1
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:WO-2024165450-A1
优先权日:2023-02-09
标题:Method of chemical synthesis of single-chain antibody fragments and products thereby obtained
发明人：FIGINI MARIANGELA; LUISON ELENA
权利人:GLYTECH INC; FIGINI MARIANGELA
摘要:A new method is disclosed for the protein full-chemical synthesis of single-chain antibody fragments (scFv); the obtained products are structurally close and functionally equivalent to their biological counterpart, being however, advantageously free of impurities and more reproducible in properties. The method includes the general steps of: (a) separately synthetizing sub-sequences (peptide fragments) (b) sequentially assembling the sub-sequences obtained in step (a) in the order as they appear in the target scFv amino acid sequence, and (c) performing oxidative folding of the assembled whole peptide molecule obtained in step (b) and dialyzing the resulting product in a buffer.

专利号:US-8404804-B2
优先权日:2007-08-28
标 题 :Methods and intermediates for chemical synthesis of polypeptides and proteins
发明人：DONG ZHENG XIN; EYNON JOHN S
权利人:DONG ZHENG XIN; EYNON JOHN S; IPSEN PHARMA SAS
摘要:The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride.

专利号:US-8153361-B1
优先权日:2006-02-06
标题:Dynamic and combinatorial synthesis of polymerase primers
发明人：BENNER STEVEN ALBERT
权利人:BENNER STEVEN ALBERT
摘要:This invention relates to the field of nucleic acid chemistry, more specifically to compositions of matter that are nucleic acid analogs, and processes that use them. Still more specifically, these compositions comprise two fragments of DNA-like molecules, each having one or more ends modified to carry a reactive group, where the reactive group on one fragment can form a transient covalent bond with the reactive group on the other under conditions of dynamic equilibrium to form a composite, where the composite can then bind to a target oligonucleotide, such as a DNA or RNA molecule. Most specifically, once the transient covalent bond forms, the composite serves as a primer for a template-directed polymerization using a DNA polymerase, an RNA polymerase, or a reverse transcriptase. Once incorporated, the epimerization causes the base pair to be destabilized, the duplex containing the epimerized nucleoside to likewise be destabilized, and the double strand to then disassociate. This leaves the template available to template the synthesis of another complementary oligonucleotide containing the epimerizing base.

专利号:US-10487099-B2
优先权日:2017-06-30
标 题:Synthesis of hypervalent iodine reagents with dioxygen
发明人：POWERS DAVID CHARLES; MAITY ASIM; HYUN SUNG-MIN
权利人:TEXAS A & M UNIV SYS
摘要:Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.