CAS: 5735-41-1; 1-Hydroxy-2,1-Benzoxaborolane

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CAS号118-44-5 N-乙基-1-萘胺 | CAS号40138-16-7 2-甲酰基苯硼酸 | CAS号100-61-8 N-甲基苯胺 | CAS号103-69-5 N-乙基苯胺 | CAS号5419-55-6 硼酸三异丙酯 | CAS号18982-54-2 2-溴苄醇 | CAS号91983-14-1 2-(溴甲基)苯硼酸 | CAS号377780-72-8 2-溴甲基苯硼酸频哪醇酯 | CAS号16419-60-6 2-甲基苯硼酸 | CAS号100299-22-7 tris(2-chlorome... | CAS号110409-93-3 4-benzylidene-1... | CAS号118803-40-0 2-羟甲基-5-硝基苯基硼酸 | CAS号90-01-7 2-羟基苄醇 | CAS号117098-94-9 6-氨基苯并[c][1,2]氧...

2-甲酰基苯硼酸置于sodium Tetrahydroborate体系中,用 甲醇 作为反应溶剂,化学反应生成 2-(羟甲基)苯硼酸环状单酯
参考文献:取代基对苯并恶唑硼烷结构和性能的影响
标题:取代基对苯并恶唑硼烷结构和性能的影响
摘要:合成了在氧杂硼酸环中具有芳基取代基的苯并氧杂硼酸,并通过单晶x射线衍射确定其结构.固态结构是具有两个分子间氢键的中心对称二聚体.使用光谱学和计算方法的组合研究了这些化合物,并将它们的性质与未取代的化合物进行了比较.通过在溶液中的1 H,13 C和11 B NMR光谱对所研究的化合物进行表征.分配1 H和13基于hsqc和hmbc光谱产生c信号.通过扩展的6-311 ++ G(d,P)基集,通过密度泛函(b3Lyp)方法计算1,3-二氢-1-羟基-3-苯基-2,1-苯并恶硼烷的分子结构.将计算出的几何参数与实验x射线数据进行比较,发现实验值与计算值之间的差异约为实验标准偏差,从而证实了这一理论水平的非常好描述.使用b3Lyp方法计算了该化合物及其氘代类似物的谐波频率,势能分布(ped)和ir强度.实验光谱的分配是基于计算出的ped进行的.二聚体形成的结果是将振动模式分裂为对称和反对称振动.提出了由氢键二聚体形成引起的结构修饰.
DOI:10.1021/jp9086283

专利信息

专利号:US-8106031-B2
优先权日:2006-05-02
标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-2025082766-A1
优先权日:2022-03-31
标 题 :Treatment of brain tumors by targeting the cholesterol pathway in astrocyes
发明人：MAYO LIOR
权利人:UNIV RAMOT
摘要:A method of treating a brain tumor in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating activity or expression of a component of the lipid synthesis and/or transportation pathways in an astrocyte in the tumor microenvironment and/or a therapeutically effective amount of a molecule which is associated with lipid uptake by the tumor cells or immune cells in the tumor microenvironment, or a polynucleotide encoding same.

专利号:AU-2020409711-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins

专利号:EP-4076533-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins

专利号:US-2018161300-A1
优先权日:2015-05-11
标题:Citrin inhibitors for the treatment of cancer
发明人：EREZ AYELET; RABINOVICH SHIRAN; SILBERMAN ALON; AGRON SHANI
权利人:YEDA RES & DEV; YEDA RES & DEV
摘要:Provided are methods, pharmaceutical compositions and kits for treating cancer in a subject in need thereof, by administering to the subject a therapeutically effective amount of an agent which downregulates a mitochondrial aspartate-dependent pyrimidine synthesis, thereby treating the cancer.

专利号:CA-3164962-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins