CAS: 5469-66-9; Propane-1,3-Diyl Bis(4-Methylbenzenesulfonate)

上下游产品

CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号504-63-2 1,3-丙二醇 | CAS号56187-12-3 N-tosyl-bis(3-h... | CAS号627-42-9 2-氯乙基甲基醚 | CAS号52667-88-6 1,4,7,10-四甲苯磺酰-... | CAS号1081-75-0 1,3-二苯基丙烷 | CAS号627-31-6 1,3-二碘丙烷 | CAS号7730-45-2 1-(P-TOLUENESUL... | CAS号67761-04-0 1,5-Diaz°Cine,o... | CAS号35980-65-5 1,4,7-tris-(4-m... | CAS号312-68-5 3-氟丙基 4-甲基苯磺酸酯 | CAS号3722-82-5 2-(3-naphthalen... | CAS号71089-74-2 1,4,8,11-四[(4-甲...

对甲苯磺酰氯,1,3-丙二醇置于吡啶体系中,化学反应 3.0H,以99%的收率获得产物1,3-丙二醇-二-间-甲苯磺酸盐
参考文献:亲脂性1-[18F]氟烷基-2-硝基咪唑的合成和表征,用于低氧成像.
标题:亲脂性1-[18F]氟烷基-2-硝基咪唑的合成和表征,用于低氧成像.
摘要:为了开发脑缺氧的新的成像标记,合成了两种亲脂性硝基咪唑,1-(3-氟丙基)-2-硝基咪唑(fpn)和1-(8-氟辛基)-2-硝基咪唑(fon),并用氟标记-18.测量辛醇/水分配系数作为亲脂性的指标,分别给出fpn的logp = 0.28和fon的logp = 2.72的值,该值被认为是分子在血脑中扩散的最佳范围屏障.通过对v79细胞进行体外放射增敏的比较研究表明,这些亲脂性类似物的还原电位可能与已知的低氧细胞放射增敏剂氟咪唑(fmiso)和米诺唑(miso)的还原电位接近.18F标记的fon(18Fon)和fpn(18Fpn)的制备是通过两步完成甲苯磺酸酯前体的[18F]氟离子置换,以合理的放射化学产率进行的.研究了静脉注射后正常大鼠和荷瘤小鼠中18Fpn和18Fon的组织分布,并与18F标记的fmiso(18Fmiso)(一种公认的低氧显像剂)的行为进行了比较.相对于18Fmiso,1
DOI:10.1248/bpb.22.590

专利信息

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-7847092-B2
优先权日:2004-12-15
标题:Method for preparation of F-18 containing organofluoro compounds in alcohol solvents
发明人：MOON DAE HYUK; CHI DAE YOON; KIM DONG WOOK; OH SEUNG JUN; RYU JIN-SOOK
权利人:FUTURECHEM CO LTD; ASAN FOUNDATION
摘要:The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

专利号:US-9764047-B2
优先权日:2009-04-17
标题:Method for obtaining novel derivatives of naphthalene for the in vivo diagnosis of alzheimer's disease
发明人：SABLÓN CARRAZANA MARQUIZA; RODRIGUEZ-TANTY CHRYSLAINE; PERERA PINTADO ALEJANDRO; RIVERA MARRERO SUCHITIL; PEREZ PERERA RAFAELA; LÓPEZ BARROSO ROSA MARIA; PRATS CAPOTE ANAIS; VÉLEZ CASTRO HERMÃ?N; PÉREZ MARTÃ?NEZ CARLOS SERAFIN; VALDÉS SOSA PEDRO
权利人:SABLÓN CARRAZANA MARQUIZA; RODRIGUEZ-TANTY CHRYSLAINE; PERERA PINTADO ALEJANDRO; RIVERA MARRERO SUCHITIL; PEREZ PERERA RAFAELA; LÓPEZ BARROSO ROSA MARIA; PRATS CAPOTE ANAIS; VÉLEZ CASTRO HERMÃ?N; PÉREZ MARTÃ?NEZ CARLOS SERAFIN; VALDÉS SOSA PEDRO; CENTRO DE NEUROCIENCIAS DE CUBA
摘要:This invention relates to a chemistry branch, particularly to the field of compounds' organic synthesis that belongs to the aromatic bicyclic or naphthalene category, used in the detection of amyloid sheets. These new naphthalene derivatives have a general formula: Wherein R represents mutually independent groups. In I: R 1 :-alkylenyl-C(O)NH-alkylenyl-R 3 , -alkylenyl-C(O)O—R 4 , R 3 :—COOH, —OH, —SH, —NH 2 , -alkyl-NH-alkyl-N-dithiocarbamate alkaline earth metal salts, R 4 : H, succinimidyl group, R 2 : —H,-alkyl. In II: R 1 : -alkyl, -alkylenyl-halide-alkylenyl-hydroxyl-alkylenyl-O-aryl, —O-alkylsulfonate alkylenyl, R 2 : -halide-alkylenyl-O-aryl, -alkylenyl-O-alkylsulfonate, -alkylenyl-halide-, —CH(O), —HCâ•?C(CN) 2 , —HCâ•?CHNO 2 , -alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl-N-dithiocarbamate alkaline salts. The terms “alkylâ€? and “alkylenylâ€? refer to linear or branched aliphatic chains, preferably from 1 to 4 carbon atoms and the term halide to fluorine, bromine or iodine. These compounds are neutral, lipophilic and have low molecular weight and therefore they cross the blood brain barrier and attach to the amyloid sheets. The present invention provides procedures for obtaining naphthalene derivatives with good yields, which can be practical, economical and adapted to a larger-scale manufacturing. We are unaware whether th compounds presented in this invention have been previously reported.

专利号:US-2018318456-A1
优先权日:2012-08-10
标题:Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:US-2020230264-A1
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:WO-2014026079-A2
优先权日:2012-08-10
标题 :Compositions, methods, and systems of the synthesis and use of imaging agents