CAS: 5417-82-3; 2-(1-Ethoxyethylidene)Malononitrile

相似化合物

123-06-8 95689-38-6 35260-96-9

上下游产品

Triethyl orthoacetate malononitrile 4-amino-2,6-dimethylpyrimidine-5-carbonitrile 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile 1,3-dimethyl-5-amino-1H-pyrazole-4-carbonitrile 5-amino-3-methyl-1H-pyrazole-4-carbonitrile

📜原乙酸三乙酯,丙二腈 反应 0.75H,以99%的收率获得产物2-(1-乙氧基亚乙基)丙二腈
参考文献:作为具有新型结合模式的 Pdhc-E1 抑制剂的 2,6-二甲基-4-氨基嘧啶腙的设计,合成和抗真菌活性
标题:作为具有新型结合模式的 Pdhc-E1 抑制剂的 2,6-二甲基-4-氨基嘧啶腙的设计,合成和抗真菌活性
摘要:一系列新型 2,6-二甲基-4-氨基嘧啶腙5被合理设计和合成为丙酮酸脱氢酶复合物 E1 (Pdhc-E1) 抑制剂.化合物5强烈抑制大肠杆菌(e.Coli)pdhc-E1(ic 50值为 0.94-15.80 μm).分子对接,定点诱变,酶促和抑制动力学分析表明,化合物5竞争性抑制 Pdhc-E1 并以"直线"模式结合在大肠杆菌pdhc-E1 活性位点,这是一种新的结合模式. 在体外抗真菌试验中,大多数化合物5在50μg/ Ml的显示针对六个测试植物病原性真菌,包括菌丝生长超过80%的抑制灰霉病,念珠菌fructigena,炭疽病菌,和葡萄座腔dothidea侵染.值得注意的是,5F和5I对m. Fructigena 的效力是商业杀菌剂克菌丹和百菌清的1.8-380 倍.在体内,与商业杀菌剂戊唑醇相比,5F和5I控制m. Fructigena的生长.因此,5F和5I对防治果蝇桃褐腐病具有潜在的商业价值.
DOI:10.1021/acs.Jafc.0C07701

专利信息

专利号:US-3803148-A
优先权日:1971-10-15
标题:Isoxazolopyrimidine herbicides and method of controlling plant growth
发明人：GIBBONS L
权利人:FMC CORP
摘要:COMPOUNDS CONSISTING OF 3,6 - DIALKYLISOXAZOLO (3,4-D) PYRIMIDIN-4-ONES EXHIBITS PRE-EMERGENCE AND POST-EMERGENCE HERBICIDAL ACTIVITY, CONTROLLING EFFECTIVELY A WIDE SPECTRUM OF GRASSY AND BROAD-LEAFED PLANT SPECIES AT RATES BELOW ONE-HALF POUND PER ACRE. THE SYNTHESIS OF MEMBERS OF THIS CLASS IS DESCRIBED IN DETAIL AND THE UTILITY OF REPRESENTATIVE COMPOUNDS IS EXEMPLIFIED.

专利号:US-3859075-A
优先权日:1971-10-15
标 题:Isoxazolpyrimidine herbicides and method of controlling plant growth
发明人：GIBBONS LOREN KENNETH
权利人:FMC CORP
摘要:A new class of herbicidal compounds consisting of 3,6dialkylisoxazolo(3,4-d)pyrimidin-4-ones exhibits pre-emergence and post-emergence herbicidal activity, controlling effectively a wide spectrum of grassy and broad-leafed plant species at rates below one-half pound per acre. The synthesis of members of this class is described in detail, and the utility of representative compounds is exemplified.

专利号:US-2005020616-A1
优先权日:2003-07-21
标 题 :Aryl fused azapolycyclic compounds
发明人：COE JOTHAM W; O'DONNELL CHRISTOPHER J
权利人:PFIZER
摘要:This invention is directed to compounds of the formula (I): n n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 and Z are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.

专利号:US-7205300-B2
优先权日:1997-12-31
标 题:Aryl fused azapolycyclic compounds
发明人：COE JOTHAM WADSWORTH; BROOKS PAIGE ROANNE PALMER
权利人:PFIZER
摘要:This invention is directed to compounds of the formula (I): n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.