CAS: 53929-59-2; 4-Methylpyridine-2,3-Diamine

该化合物是一种多用途芳香二胺化合物,其特点是以甲基和氨基功能组取代了核核心,这种结构具有适合医药中间体,农用化学合成和协调化学应用的回活动性;邻近的氨基基组的存在能够与金属离子发生切热,使其在催化剂设计和材料科学中具有价值;其甲基替代可增强有机溶剂中的溶解性,有利于合成改造;该化合物的稳定性和明确界定的再活动特征有助于其在热循环化学中的效用,特别是在建造引信环系统方面;由于对空气和水分的潜在敏感性,建议谨慎处理.

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6635-86-5 50850-16-3 452-58-4

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上下游产品

2-amino-4-methyl-3-nitropyridine 3-Amino-4-methyl-pyridin-1-oxid 4-methyl-2-nitropyridin-3-amine 4'-(2-Ethyl-7-methyl-imidazo[4,5-b]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid amide pyridine2,7-Dimethylimidazo4,5-bpyridine 2-Methyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 2-Methyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide

合成工艺路线路线简述

    📜4-甲基-3-吡啶胺1-氧化物置于盐酸体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 4-甲基-2,3-二氨基吡啶
    参考文献:Substituted 2-Aminopyridines As Inhibitors Of Nitric Oxide Synthases
    标题:Substituted 2-Aminopyridines As Inhibitors Of Nitric Oxide Synthases
    摘要:A Series Of Substituted 2-Aminopyridines Was Prepared And Evaluated As Inhibitors Of Human Nitric Oxide Synthases (Nos). 4,6-Disubstitution Enhanced Both Potency And Specificity For The Inducible Nos With The Most Potent Compound Having An Ic50 Of 28 Nm. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
    DOI:10.1016/s0960-894X(00)00389-9

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    专利信息


    专利号:US-2008312271-A1
    优先权日:2006-07-25
    标 题 :Azabenzimidazolyl compounds
    发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S
    权利人:PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-2005113397-A1
    优先权日:2002-01-31
    标题:Imidazo[1,2-a]pyridine derivative
    发明人：TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI
    摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.

    专利号:CA-2482705-A1
    优先权日:2002-04-17
    标题:Use of meglumine for inhibiting 3-deoxyglucosone synthesis in the skin

    专利号:CA-2482705-C
    优先权日:2002-04-17
    标题 :Use of meglumine for inhibiting 3-deoxyglucosone synthesis in the skin

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    合成参考文献


    参考文献:10.1007/s11164-022-04882-8
    摘要:Dolejšová Sekerová L, Vavříková Z, Do TT, Vyskočilová E, Červený L. High-yielding preparation of fragrance Clarycet via two-step synthesis. Research on Chemical Intermediates. 2022 Nov 27;():1–11. doi: 10.1007/s11164-022-04882-8.
    参考文献:10.1016/s0960-894x(00)00389-9
    摘要:Hagmann WK, Caldwell CG, Chen P, Durette PL, Esser CK, Lanza TJ, Kopka IE, Guthikonda R, Shah SK, MacCoss M, Chabin RM, Fletcher D, Grant SK, Green BG, Humes JL, Kelly TM, Luell S, Meurer R, Moore V, Pacholok SG, Pavia T, Williams HR, Wong KK. Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. Bioorganic & Medicinal Chemistry Letters. 2000 Sep;10(17):1975–8. doi: 10.1016/s0960-894x(00)00389-9.
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