CAS: 481-74-3; 1,8-Dihydroxy-3-Methylanthracene-9,10-Dione

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3-(溴甲基)-1,8-二羟基-9,10-蒽二酮置于10Percent Pd/c 氢气体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以780 Mg的收率获得产物大黄酚
参考文献:Knipholone和相关抗疟原虫苯基蒽醌的对映体对映选择性全合成.
标题:Knipholone和相关抗疟原虫苯基蒽醌的对映体对映选择性全合成.
摘要:"内酯概念"已被有效地用于苯丙醚酮和相关的天然苯基蒽醌的第一次熵-对映选择性合成.除了对联芳基轴的区域和立体选择性构建之外,另一个重要步骤是通过合成的乙酰弗里德-克拉夫茨型乙酰化反应或通过首先在简化模型上测试的邻位选择性弗里斯重排"合成后期"引入c-乙酰基系统并随后应用于天然产品及其简化类似物的高度阻转选择性制备以进行生物测试.这些天然联芳基,其前体和非天然类似物的合成可用性使得人们对这些有趣的联芳基的抗血浆活性进行了更广泛的研究.
DOI:10.1021/jo020189S

专利信息

专利号:US-6531591-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人：FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:EP-1202998-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人：FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:EP-1202998-A1
优先权日:1999-07-07
标题:Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates

专利号:US-9321804-B2
优先权日:2011-03-09
标题 :Synthesis and use of anti-tumor drug LQC-Y
发明人：LEI HAIMIN
权利人:UNIV BEIJING CHINESE MEDICINE; 3D MEDICINES LTD
摘要:Disclosed are the general structural formula of LQC-Y as well as the synthesis and use thereof. Pharmacological experiments demonstrated the marked antitumor effect of such compounds. Single day administration of LQC-Y3 to mice at a maximum dose of 6000 mg/kg showed no toxicity response during the 14-day continuous observation period, indicating the high safety of the compounds, and the compounds can be used to prepare medicaments for preventing and treating carcinomas such as liver cancer, lung cancer. In the general structural formula of LQC-Y, R represents steroid compounds such as cholic acid, deoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid, and hyodeoxycholic acid and so on; triterpenoid compounds such as oleanolic acid, ursolic acid, pachymic acid, glycyrrhetinic acid and glycosides thereof and so on; emodic acid, emodin and other mono-substituted or poly-substituted structures of anthraquinone parent nucleus; baicalein, baicalin and other flavonoid; shikimic acid, mono-substituted shikimic acid or poly-substituted shikimic acid; gardenia acid and other iridoid acid derivatives; paeonol, curcumin and structural derivatives thereof.

专利号:DE-60006680-T2
优先权日:1999-07-07
标题 :SYNTHESIS OF STABLE CHINONE- AND PHOTOREACTIVE KETONE-PHOSPHORAMIDITE REAGENT FOR SOLID-PHASE SYNTHESIS OF PHOTOREACTIVE OLIGOMER CONJUGATES

专利号:WO-0104129-A1
优先权日:1999-07-07
标题:Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates