CAS: 37595-74-7; 1,1,1-Trifluoro-N-Phenyl-N-((Trifluoromethyl)Sulfonyl)Methanesulfonamide

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456-64-4 52331-16-5 950578-84-4

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CAS号358-23-6 三氟甲磺酸酐 | CAS号1025373-45-8 trifluoromethan... | CAS号109613-00-5 4-乙酰苯基三氟甲烷磺酸酯 | CAS号109459-28-1 (3-ox°Cyclohexe... | CAS号1046793-55-8 4-MORPHOLIN°CYC... | CAS号3857-83-8 三氟甲烷磺酸2-萘酯 | CAS号144464-64-2 5-氧代-5,6,7,8-四氢... | CAS号145372-33-4 2,3,3a,6,7,7a-H... | CAS号144242-09-1 2-三氟甲基磺酰氧基-1-环庚... | CAS号188112-49-4 3,5-二甲基-4-三氟甲烷磺... | CAS号189894-13-1 (3S,5S)-3,5-二(叔... | CAS号202923-79-3 (2-oxo-1H-quino...

三氟甲磺酸酐,苯胺置于三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 12.0H,以89%的收率获得产物n-苯基双(三氟甲烷磺酰)亚胺
参考文献:由静电相互作用引导的空间偏置和无偏置衬底的元选择性 C-H 硼酸化
标题:由静电相互作用引导的空间偏置和无偏置衬底的元选择性 C-H 硼酸化
摘要:描述了空间偏压和无偏压底物的静电定向代谢硼化.硼酸化遵循配体和底物之间部分正电荷和负电荷之间的静电相互作用.使用这种策略,已经证明大量具有挑战性的底物,尤其是 4 取代底物,可以在间位选择性地硼酸化.此外,未取代的底物也表现出优异的间位选择性.该反应采用实验室稳定的配体并在较温和的温度下进行,无需合成庞大而复杂的配体/模板.
DOI:10.1021/jacs.1C01770

专利信息

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-9994508-B2
优先权日:2012-12-11
标 题:Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives
发明人：LOPEZ PEREZ BORJA; SIGUEIRO PONTE RITA; MAESTRO SAAVEDRA MIGUEL A; MOURINO MOSQUERA ANTONIO
权利人:ENDOTHERM GMBH
摘要:Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.

专利号:US-9604911-B2
优先权日:2013-12-05
标题 :Process for the synthesis of agomelatine
发明人：BRIERE JEAN-FRANÇOIS; LEBEUF RAPHAËL; LEVACHER VINCENT; HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I):

专利号:US-5597931-A
优先权日:1992-03-30
标 题:Total synthesis of taxol and analogues thereof
发明人：DANISHEFSKY SAMUEL J; MASTERS JOHN; YOUNG WENDY; LINK J THOMAS; ISAACS RICHARD; SNYDER LAWRENCE B
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.