CAS: 35080-11-6; Prajmaline

该化合物是被归类为抗心律激素的一种化学化合物,主要用于治疗某些类型的心律不全,属于被称为IA类抗心律的药物,它通过阻塞心脏细胞中的钠管而发挥作用,从而稳定心膜膜,减少...

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    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2008107598-A1
    优先权日:2006-10-05
    标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

    专利号:AU-2007308022-B2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:CA-2664826-C
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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    主要参考文献


    1: Piekarska A. [Cholestatic hepatitis caused by prajmalium treatment: case report]. Pol Arch Med Wewn. 2003 Jun;109(6):629-32. Polish. German. Hungarian. Polish. German. French.

    合成参考文献


    参考文献:10.1016/0002-8703(80)90732-2
    摘要:Bussmann WD, Schreiber S, Kaltenbach M. Comparison of antiarrhythmic effects of oral prajmalium bitartrate and intravenous lidocaine in acute myocardial infarction. Am Heart J. 1980 May;99(5):589–97. doi: 10.1016/0002-8703(80)90732-2.
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