CAS: 30578-37-1; 4-Amino-6-Methoxy-1-Phenylpyridazin-1-Ium Methyl Sulfate

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

    氯草敏置于镍 氢气体系中,用 Ammonium Hydroxide,氯仿 用作溶剂,110.0 °C,5.0 Mpa 条件下,反应 0.5H,反应生成甲磺美嗪
    参考文献:Reicheneder; Burger; Koenig,Arzneimittel-Forschung/drug Research,1981,Vol. 31,# 9 A,P. 1529-1533
    标题:Reicheneder; Burger; Koenig,Arzneimittel-Forschung/drug Research,1981,Vol. 31,# 9 A,P. 1529-1533

    海关参考信息

    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2008107598-A1
    优先权日:2006-10-05
    标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

    专利号:AU-2007308022-B2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
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    主要参考文献


    1: Kobayashi M. Diffuse cerebrovascular dilation: Case report of amezinium metilsulfate-induced reversible cerebral vasoconstriction syndrome. Cephalalgia. 2016 Mar;36(3):289-93. doi: 10.1177/0333102415588326. Japanese. Japanese. Japanese.

    合成参考文献


    摘要:Yakuri to Chiryo. Pharmacology and Therapeutics., 16(1471), 1988
    参考文献:10.1007/s00210-008-0272-0
    摘要:Wenge B, Bönisch H. N-Ethylmaleimide differentially inhibits substrate uptake by and ligand binding to the noradrenaline transporter. Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):255–65. doi: 10.1007/s00210-008-0272-0.
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