CAS: 29885-95-8; N-Methylaniline 2,2,2-Trifluoroacetate

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CAS号100-61-8 N-甲基苯胺 | CAS号76-05-1 三氟乙酸(TFA) | CAS号1489-50-5 2-亚甲基环戊酮 | CAS号59819-62-4 1-Cyclopropyl-2...

📜N-甲基苯胺,三氟乙酸 以 乙醇 用作溶剂,-10.0~38.0 °C,100.0 Pa 条件下,反应生成氮甲基苯胺三氟乙酸
参考文献:High-Throughput Approach For The Identification Of Anilinium-Based Ionic Liquids That Are Suitable For Electropolymerisation
标题:High-Throughput Approach For The Identification Of Anilinium-Based Ionic Liquids That Are Suitable For Electropolymerisation
摘要:我们报道了基于苯胺衍生物的新型质子离子液体(pils)的合成,并使用高通量(ht)技术筛选可能的候选物.
Doi:10.1039/c5Cp02294K

专利信息

专利号:US-2011184058-A1
优先权日:2008-07-14
标 题:Synthesis of 6,7-dihydro-1h-indeno[5, 4-b] furan-8(2h)-one as intermediate in the preparation of remelteon
发明人：CLUZEAU JEROME
权利人:LEK PHARMACEUTICALS
摘要:The present invention describes the preparation of 6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one, a key intermediate in preparation of ramelteon. The present invention also describes further preceding intermediate compounds useful for the synthesis of 6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one.

专利号:US-7897758-B2
优先权日:2005-04-27
标题 :Activators for oligonucleotide and phosphoramidite synthesis
发明人：WOLTER ANDREAS; LEUCK MICHAEL
权利人:SIGMA ALDRICH CO
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides and nucleoside phosphoramidites. The methods are based on employing aryl-substituted 5-phenyl-1H-tetrazoles with perfluoroalkyl groups on the aromatic ring as activators. In one aspect the novel activators are used in the synthesis of oligonucleotides via the phosphoramidite approach. In this aspect the activators are highly efficient and can be applied with very short coupling times. In a further aspect, the activators of the invention are used in the synthesis of phosphoramidites through the reaction of nucleosides comprising a free hydroxyl group with phosphitylating agents. In this aspect the activators provide very pure phosphoramidites under mild conditions. The activators of the invention are further characterized by being highly soluble, non-hygroscopic and non-hazardous.

专利号:US-2012083526-A1
优先权日:2009-04-07
标 题:Synthesis of 1-(2,3-dihydrobenzofuran-4-yl)ethanone as intermediate in the preparation of ramelteon
发明人：CLUZEAU JEROME
权利人:CLUZEAU JEROME; LEK PHARMACEUTICALS
摘要:The present invention relates in general to the field of organic chemistry and in particular to the preparation of 1-(2,3-dihydrobenzofuran-4-yl)ethanone, an intermediate in preparation of (S)—N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide, i.e. ramelteon.

专利号:US-6809195-B1
优先权日:2000-08-16
标 题:Process for the preparation of oligonucleotides
发明人：SANGHVI YOGESH S; SONG QUANLAI
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention discloses methods for synthesizing oligomeric compounds. The methods include a modified phosphoramidite protocol wherein the oxidation and capping steps are combined into a single step. The methods result in increased efficiency and are especially amenable to the large scale synthesis of oligomeric compounds.

专利号:WO-2010115897-A2
优先权日:2009-04-07
标 题:Synthesis of 1-(2,3-dihydrobenzofuran-4-yl)ethanone as intermediate in the preparation of ramelteon

专利号:US-6762281-B2
优先权日:2000-09-08
标题:Process for preparing peptide derivatized oligomeric compounds
发明人：MANOHARAN MUTHIAH; GUZAEV ANDREI P
权利人:ISIS PHARMACEUTICALS INC
摘要:Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the synthesis of peptide linked oligomeric compounds is performed without the problems of aggregation associated with electrostatic interactions. The present method describes using equimolar amounts of oligomeric compounds and peptide reagents providing for an increase in overall efficiency.