CAS: 262268-58-6; (E)-3-(3-(Trifluoromethyl)Phenyl)Acrylaldehyde

上下游产品

(E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol acrylaldehyde diethyl acetal m-trifluoromethylphenyl iodide 3-Trifluoromethylbenzaldehyde trans-4,4-dimethyl-2-(m-trifluoromethylstyryl)-1,3-oxathiane tert-butyl-dimethyl-[1-trichloromethyl-3-(3-trifluoromethyl-phenyl)-allyloxy]-silanetert-butyl-dimethyl-[1-trichloromethyl-3-(3-trifluoromethyl-phenyl)-allyloxy]-silane 3-[3-(trifluoromethyl)phenyl]propan-1-ol (E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol

📜3-三氟甲基苯甲醛置于manganese(Iv) Oxide,Sodium Hydride,二异丁基氢化铝体系中,用 乙二醇二甲醚,二氯甲烷,甲苯 用作溶剂,化学反应 2.83H,反应生成间三氟甲基肉桂醛
参考文献:Synthesis And Antifungal Activities Of R-102557 And Related Dioxane-Triazole Derivatives.
标题:Synthesis And Antifungal Activities Of R-102557 And Related Dioxane-Triazole Derivatives.
摘要:具有二噁烷环的新型三唑化合物被合成.在酸性条件下,二醇前体10与各种芳香醛11-13缩合,得到了一系列二噁烷-三唑化合物14-16.这些化合物14-16的抗真菌活性通过在小鼠感染模型中对白色念珠菌和曲霉菌的评估进行了体内评价.含有单个或两个双键且侧链上带有吸电子基团的芳环衍生物表现出较高的活性.在这些衍生物中,R-102557(16R:Ar=4-(2,2,3,3-四氟丙氧基)苯基)对白色念珠菌,曲霉菌和隐球菌属表现出极佳的体内活性.在大鼠的初步毒性研究中也显示出高度耐受性.
Doi:10.1248/cpb.48.694

专利信息

专利号:US-8614354-B2
优先权日:2008-06-18
标题 :Process for the synthesis of cinacalcet hydrochloride
发明人：FERRARI MASSIMO; GHEZZI MARCELLO; BONALDI MATTEO
权利人:FERRARI MASSIMO; GHEZZI MARCELLO; BONALDI MATTEO; ERREGIERRE SPA
摘要:There is described a process for the preparation of cinacalcet hydrochloride (I) which includes the steps of: a) reacting (R)-(+)-1-(1-naphthyl)ethylamine (II) with 3-[3-(trifluoromethyl)phenyl]propenaldehyde (III) to afford the non isolated intermediate (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino-N-[1-(1-naphthyl)ethylamine (IV); b) reducing the non isolated intermediate (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino-N-[-1-(1-naphthyl)ethylamine (IV) with a sequential addition of:—a solution of sodium borohydride, methanol and a base,—oxalic acid and—a base to obtain (R)—N-[3-[3-(tifluoromethyl)phenyl]-2-propenyl]-1-(1-naphthyl)ethylamine (V) by passing through the precipitation of the oxalate salt of compound (V) after the addition of oxalic acid; c) hydrogenating (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenyl]-1-(1-naphthyl)ethylamine (V) thus obtaining (R)—N-(3-(3-(trifluoromethyl)phenyl]propyl]-1-(1-naphthyl)ethylamine cinacalcet base (VI), which is retaken in ethyl acetate; and d) treating the solution of cinacalcet base (VI) in ethyl acetate with hydrochloric acid to afford cinacalcet hydrochloride (I).

专利号:US-2011105799-A1
优先权日:2008-06-18
标 题 :process for the synthesis of cinacalcet hydrochloride

专利号:EP-2321256-A1
优先权日:2008-06-18
标 题:A process for the synthesis of cinacalcet hydrochloride

专利号:EP-2321256-B1
优先权日:2008-06-18
标题 :Process for the synthesis of cinacalcet hydrochloride

专利号:WO-2009153814-A1
优先权日:2008-06-18
标题 :A process for the synthesis of cinacalcet hydrochloride

专利号:US-10829464-B2
优先权日:2016-11-23
标题 :Benzoheterocyclic alkylamine compounds and use thereof
发明人：LI JIAN; LAN LEFU; LI BAOLI; CHEN FEIFEI; NI SHUAISHUAI; LIU YIFU; WEI HANWEN; MAO FEI; ZHU JIN
权利人:UNIV EAST CHINA SCIENCE & TECH; SHANGHAI INST MATERIA MEDICA CAS
摘要:Disclosed are benzoheterocyclic alkylamine compounds, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and a preparation method thereof, and use of the same in the manufacture of an antibacterial drug as an inhibitor of staphyloxanthin synthesis in Staphylococcus aureus .