CAS: 2199-44-2; Ethyl 3,5-Dimethyl-2-Pyrrolecarboxylate

该化合物是一种火花衍生物,在有机合成和制药研究方面非常有用,其结构以一个碳酸酯酯类和甲基替代成分为特点,使其成为建造复杂的七环化合物的多用途中间体.该化合物在标准条件下具有稳定性,在普通有机溶剂中可溶解,便于在循环和功能性组变等反应中使用.其明确界定的再活性特征可以进行精确的修改,使其对开发生物活性分子和材料具有价值.该酯还允许进一步衍生,加强其在医药化学和农用化学研究中的应用性.

结构式图片

相似化合物

2199-58-8 4513-93-3 3284-47-7

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号6829-41-0 异亚硝基丙二酸二乙酯 | CAS号123-54-6 乙酰丙酮 | CAS号2386-26-7 3-乙酰-2,4-二甲基-5乙氧羰基吡咯 | CAS号105-56-6 氰乙酸乙酯 | CAS号131992-04-6 ethyl 4-[bis(ac... | CAS号2199-64-6 4-甲酰基-3,5-二甲基-1... | CAS号102943-48-6 3-methyl-2-nitr... | CAS号131992-05-7 ethyl 4-[bis(ac... | CAS号4513-93-3 3,5-二甲基-2-吡咯羧酸 | CAS号220845-12-5 1H-Pyrrole-2-ca... | CAS号24014-19-5 4-甲基-1H-吡咯-2-甲醛 | CAS号26018-30-4 Ethyl 5-formyl-... | CAS号625-82-1 2,4-二甲基吡咯 | CAS号28991-95-9 4-叔丁基-3,5-二甲基吡咯羧酸乙酯 | CAS号1003-90-3 2,3,4,5-四甲基吡咯 | CAS号34549-87-6 4-丁基-3,5-二甲基-1H... | CAS号134209-74-8 5-甲酰基-3-甲基-1H-吡... | CAS号2199-58-8 3,5-二甲基-2-吡咯甲醛

合成工艺路线路线简述

  • 合成目标产物 Ethyl 3,5-Dimethyl-1H-Pyrrole-2-Carboxylate 主要起始原料 Ethyl Cyanoacetate And Acetylacetone
  • (文献来源)合成步骤主要原料 Ethyl Cyanoacetate 和 Acetylacetone
Ethyl 4--3,5-Dimethylpyrrole-2-Carboxylate置于copper Dichloride体系中,用 1,4-二氧六环 用作溶剂,化学反应 5.0H,以100%的收率获得3,5-二甲基-1H-吡咯-2-甲酸乙酯
参考文献:Monti,Donato; Sleiter,Giancarlo,Gazzetta Chimica Italiana,1990,Vol. 120,P. 771-774
标题:Monti,Donato; Sleiter,Giancarlo,Gazzetta Chimica Italiana,1990,Vol. 120,P. 771-774

海关参考信息

专利信息


专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人:CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:WO-2007141253-A1
优先权日:2006-06-07
标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
发明人:PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-2025074844-A1
优先权日:2023-08-28
标 题:Polyalphaolefins made from dimer olefins obtained from branched c10 monoolefins using solid acid catalyst
发明人:MALINSKI THOMAS; GEE JEFFREY C; BISCHOF STEVEN M; KERNS SPENCER A; HILLIER JAMES; WEBSTER-GARDINER MICHAEL S
权利人:CHEVRON PHILLIPS CHEMICAL CO LP
摘要:Synthesis of polyalphaolefins by oligomerization of one or more branched C 10 monoolefins with a solid acid catalyst to form an oligomer product, followed by hydrogenation of a C 20+ olefin portion of the oligomer product to form the polyalphaolefins. The solid acid catalyst is selective to C 20 olefin dimers.

专利号:US-2025075015-A1
优先权日:2023-08-28
标题 :Polyalphaolefins made from dimer olefins obtained from branched c10 monoolefins using alkyl aluminum catalyst
发明人:MALINSKI THOMAS; KERNS SPENCER A; LESEBERG JULIE A; GEE JEFFREY C; BISCHOF STEVEN M; HILLIER JAMES; WEBSTER-GARDINER MICHAEL S
权利人:CHEVRON PHILLIPS CHEMICAL CO LP
摘要:Synthesis of polyalphaolefins by oligomerization of one or more branched C 10 monoolefins with an alkyl aluminum catalyst to form an oligomer product, followed by hydrogenation of a C 20+ olefin portion of the oligomer product to form the polyalphaolefins. The alkyl aluminum catalyst is selective to C 20 olefin dimers.

专利号:US-7687672-B2
优先权日:2006-02-03
标 题 :In-line process for generating comonomer
发明人:BUCHANAN JOHN S; SHAFFER TIMOTHY D
权利人:EXXONMOBIL CHEM PATENTS INC
摘要:The present invention relates to an in-line method for generating comonomer, such as 1-hexene or 1-octene, from monomer, such as ethylene. The comonomer generated is directly transported, without isolation or storage, to a polyethylene polymerization reactor. The in-line method for generating comonomer includes the steps of providing an in-line comonomer synthesis reactor and a downstream gas/liquid phase separator prior to a polyethylene polymerization reactor; feeding ethylene monomer and a catalyst in a solvent to the comonomer synthesis reactor; reacting the ethylene monomer and the catalyst in solvent under reaction conditions to produce an effluent stream including ethylene monomer and comonomer; passing the effluent stream from the comonomer synthesis reactor to the downstream gas/liquid phase separator to separate a gas stream from a bottom stream, wherein the gas stream is a mixture of ethylene monomer, and comonomer; and passing the gas stream to the polyethylene polymerization reactor to provide the necessary comonomer input. The in-line method is useful in the production of LLDPE, and other branched polyethylene based polymers. Some benefits include process simplification and reduced capital and operating costs.

专利号:US-7858833-B2
优先权日:2006-02-03
标题:Process for generating linear alpha olefin comonomers
发明人:BUCHANAN JOHN S; SANKARANARAYANAN KRISHNAN; AJINKYA MILIND B; WOOD STEPHEN M; SKOULIDAS ANASTASIOS
权利人:EXXONMOBIL CHEM PATENTS INC
摘要:The present invention relates to a method for preparing linear alpha olefin comonomers, such as 1-butene, 1-hexene or 1-octene, from ethylene monomer. The comonomer generated is stored on site for use in a subsequent process, such as a polyethylene polymerization reactor. The method includes the steps of feeding an ethylene monomer, and a catalyst in a solvent to one or more comonomer synthesis reactors; reacting the ethylene monomer and the catalyst in solvent under reaction conditions to produce an effluent stream comprising unreacted ethylene monomer, a catalyst in a solvent, and comonomer; passing the effluent stream to one or more downstream gas/liquid phase separators to form a gas stream of unreacted ethylene monomer, and a liquid stream of comonomer, and catalyst in a solvent; recycling to the one or more comonomer synthesis reactors the unreacted ethylene monomer and a portion of the liquid stream; and storing a remaining portion of said liquid stream for subsequent processing of the comonomer. Some of the benefits of the method include process simplification and reduced capital and operating costs from, inter alia, not having to recover ethylene in high purity nor separate catalyst from comonomer.
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✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 346.
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