CAS: 201166-22-5; 4-Isopropyl-2,2-Dimethylbenzo[d][1,3]Dioxole

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2-(1-methylethyl)phenol 1-isopropyl-2-methoxymethyloxybenzene 3-isopropylbenzene-1,2-diol

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    📜3-异丙基邻苯二酚置于三氟化硼乙醚体系中,用 丙酮 用作溶剂,化学反应 16.0H,以71%的收率获得2,2-二甲基-4-异丙基-1,3-苯并二恶茂
    参考文献:Commercial Manufacturing Of Propofol: Simplifying The Isolation Process And Control On Related Substances
    标题:Commercial Manufacturing Of Propofol: Simplifying The Isolation Process And Control On Related Substances
    摘要:A Commercially Viable Manufacturing Process For Propofol (1) Is Described. The Process Avoids Acid-Base Neutralization Events During Isolation Of Intermediate,2,6-Di-Isopropylbenzoic Acid (3) And Crude Propofol,And Thus Simplifies The Synthesis On Industrial Scale To A Considerable Extent. Syntheses Of Five Impurities/related Substances (Usp And Ep) Are Also Described.
    Doi:10.1021/op400300T

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    参考DOI号:10.1021/op400300t
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