📜3-异丙基邻苯二酚置于三氟化硼乙醚体系中,用 丙酮 用作溶剂,化学反应 16.0H,以71%的收率获得2,2-二甲基-4-异丙基-1,3-苯并二恶茂
参考文献:Commercial Manufacturing Of Propofol: Simplifying The Isolation Process And Control On Related Substances
标题:Commercial Manufacturing Of Propofol: Simplifying The Isolation Process And Control On Related Substances
摘要:A Commercially Viable Manufacturing Process For Propofol (1) Is Described. The Process Avoids Acid-Base Neutralization Events During Isolation Of Intermediate,2,6-Di-Isopropylbenzoic Acid (3) And Crude Propofol,And Thus Simplifies The Synthesis On Industrial Scale To A Considerable Extent. Syntheses Of Five Impurities/related Substances (Usp And Ep) Are Also Described.
Doi:10.1021/op400300T