CAS: 18162-84-0; Dimethyl-N-Octylchlorosilane

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CAS号1066-35-9 二甲基一氯硅烷 | CAS号111-66-0 1-辛烯 | CAS号3429-76-3 trimethyl-°Ctyl... | CAS号17049-49-9 正辛基镁溴盐 | CAS号75-78-5 二甲基二氯硅烷 | CAS号184687-88-5 [2,5-bis(bromom... | CAS号18642-94-9 1,3-辛基四甲基二硅氧烷 | CAS号111-87-5 正辛醇 | CAS号3429-76-3 trimethyl-°Ctyl... | CAS号14799-93-0 二氯(甲基)正辛基硅烷 | CAS号64451-51-0 hydroxy-dimethy... | CAS号40934-68-7 dimethyl(°Ctyl)...

三甲基(辛基)硅烷置于c4H15B11Br6Si,1,2-二氯乙烷,苯体系中,化学反应生成氯二甲基辛硅烷
参考文献:芳烃离子催化全烷基化硅烷的卤代脱烷基化
标题:芳烃离子催化全烷基化硅烷的卤代脱烷基化
摘要:"有机硅"在自然界中并不存在,但现代化学很难想象没有硅与碳结合的情况.虽然含硅商品化学品(例如通过"直接工艺" 1,2,3,4产生的那些)看起来很简单,但选择性制备芳基取代和烷基取代(官能化)硅化合物(称为硅烷)并非易事.氯硅烷如 Me 4− N Sicl N ( N = 1-3) 以及 Sicl 4 ( N = 4) 是合成含硅分子的常见起点.然而这些方法常常遇到具有挑战性的分离问题5 .相反,具有四个烷基的硅烷被认为是合成的死角.在这里,我们介绍了芳烃离子催化的卤代脱烷基化反应,可有效地将 Me 4 Si 和相关的季硅烷转化为各种官能化衍生物.该反应使用烷基卤和芳烃(共)溶剂:烷基卤是卤化物源,最终与芳烃进行弗里德尔-克来福特烷基化以再生催化剂6,而芳烃离子则充当强布朗斯台德酸原脱烷基化步骤7 .例如,在硅药物前体的合成中,证明了自上而下的卤代烷基化方法相对于报道的自下而上程序的优势.此外,连接到烷基链上的相当惰性的me
Doi:10.1038/s41586-023-06646-9

专利信息

专利号:US-9981239-B2
优先权日:2015-04-21
标题:Devices and methods for oligonucleic acid library synthesis
发明人：BANYAI WILLIAM; PECK BILL JAMES; FERNANDEZ ANDRES; CHEN SIYUAN; INDERMUHLE PIERRE; MARSH EUGENE P
权利人:TWIST BIOSCIENCE CORP
摘要:Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.

专利号:US-11033507-B2
优先权日:2013-12-19
标 题 :Method of synthesis of silica vesicles and use thereof
发明人：YU CHENGZHONG; MITTER NEENA; ZHANG JUN
权利人:UNIV QUEENSLAND
摘要:The invention relates, in part, to a method of producing silica vesicles including under controlled conditions to thereby heavily influence the morphology and characteristics of the vesicles. The vesicles are shown to be effective as delivery agents for chemical and biological agents. They are also shown to be useful in methods of treatment and as components of an immunogenic composition.

专利号:US-4919804-A
优先权日:1988-03-01
标 题:Ultrasound driven synthesis of reversed and normal phase stationary phases for liquid chromatography
发明人：DORSEY JOHN G; SENTELL KAREN B; BARNES KAREN W
权利人:UNIV FLORIDA
摘要:In a method for producing a reversed phase bonded metal oxide by reacting the metal oxide with a reactive silane, the improvement comprising conducting the reaction in the presence of ultrasonic waves.

专利号:US-2018104664-A1
优先权日:2016-08-03
标 题 :Textured surfaces for polynucleotide synthesis
发明人：FERNANDEZ ANDRES; INDERMUHLE PIERRE; MARSH EUGENE P; BANYAI WILLIAM; PECK BILL JAMES
权利人:TWIST BIOSCIENCE CORP
摘要:Methods, devices and systems are provided herein for surfaces for de novo polynucleotide synthesis that provide for increased polynucleotide yield. Surfaces described herein comprise a texture that increases surface area provide for increased polynucleotide yield compared to non-textured surfaces. In addition, the patterned placement of nucleoside coupling reagent spanning such surfaces provides for improved synthesis yield, representation, and a reduction in contamination on the surface between different polynucleotide species.

专利号:US-2022355262-A1
优先权日:2019-07-22
标题 :System and method for manufacturing water-based hydrophobic aerogels and aerogel composites
发明人：SACHITHANADAM MAHESH; KHORASGANI SOGHRATI ELMIRA; NATARAJAN GAYATHRI
权利人:KROSSLINKER PTE LTD
摘要:Embodiments of the present invention provide users with a system and method for manufacturing water-based hydrophobic aerogels and aerogel composites. The system and method can be carried out in a manner which is more rapid than typical ways and can be readily scalable. The method of manufacture is useful for producing water based hydrophobic aerogels and aerogel composites on a large scale with good homogeneity and consistency. Advantageously, the method of manufacture also has the benefit of a shorter processing time due to the vacuum homogenizing and mixing processes, the use of microwave assisted vacuum freeze drying for ease of synthesis of water-based hydrophobic aerogels.

专利号:US-5665882-A
优先权日:1994-03-14
标题 :Pyridyl ethylation of lactams
发明人：CHUNG JOHN Y L; ZHAO DALIAN; MCNAMARA JAMES M; HUGHES DAVID L
权利人:MERCK & CO INC
摘要:PCT No. PCT/US94/12671 Sec. 371 Date Aug. 29, 1996 Sec. 102(e) Date Aug. 29, 1996 PCT Filed Nov. 7, 1994 PCT Pub. No. WO95/25101 PCT Pub. Date Sep. 21, 1995The invention is a highly efficient synthesis for making compounds of formula: wherein n=0, 1, R is C1-4 alkyl or benzyl; and R1, when present, is C1-4 alkyl, OH, O-C1-4 alkyl or S-C1-4 alkyl. The process involves silane-mediated conjugation of 4-vinylpyridine to a substituted lactam.