CAS: 1813-94-1; Ethyl 2-(4-Fluorophenyl)-2-Oxoacetate

上下游产品

ethanol 2-(4-fluorophenyl)-2-oxoacetic acid oxalic acid diethyl ester 4-flourophenylmagnesium bromideCyclohexyl-(4-fluor-phenyl)-glykolsaeure-aethylester 2-(4-fluorophenyl)-2-oxoacetic acid ethyl α,α-difluoro-α-(p-fluorophenyl)acetate (S)-(+)-1-(4-fluorophenyl)-1,2-ethanediol

📜对氟扁桃酸置于氯化亚砜,Caesium Carbonate,二甲基亚砜,三乙胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应生成4-氟苯基乙醛酸乙酯
参考文献:新型2-(3-苯基哌嗪-1-基)-嘧啶-4-酮作为糖原合酶激酶-3β抑制剂的发现
标题:新型2-(3-苯基哌嗪-1-基)-嘧啶-4-酮作为糖原合酶激酶-3β抑制剂的发现
摘要:我们在本文中描述了糖原合酶激酶(gsk)-3β抑制剂从含有2-苯基吗啉部分的有希望的化合物中进一步进化的结果.吗啉部分转化为哌嗪部分会产生有效的gsk-3β抑制剂.专注于苯基部分的sar研究表明,4-氟-2-甲氧基对gsk-3β具有有效的抑制活性.基于对接研究,已表明哌嗪部分的氮原子与gln185主链的氧原子之间存在新的氢键,与相应的苯吗啉类似物相比,这可能有助于增加活性.还讨论了苯基哌嗪部分的立体化学作用.
Doi:10.1016/j.Bmcl.2017.06.078

专利信息

专利号:US-2025222120-A1
优先权日:2024-01-09
标题 :Synthesis of novel small molecule carm1 degraders, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; XU WEI; XIE HAIBO; BACABAC MEGAN
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Provided herein are CARM1 PROTACs comprising a binding molecule of CARM1 with an optimized linker attached to an E3 ubiquitin ligase ligand that recruits the E3 ubiquitin ligase to CARM1. The PROTACs find use, e.g., for selectively targeted degradation of CARM1 protein in cancer cells. Also provided herein are compositions comprising the PROTACs, as well as methods of using the PROTACs.