CAS: 17019-92-0; 11-Keto β-Boswellic Acid

该化合物是源自Boswellia serrata树树树脂的五溴二苯醚三叶素,以其抗炎特性而著称;该化合物的特点是独特的化学结构,其中包括乙醇-生物间酸框架第11位的一个氯酮功能组;它展示了一系列生物活动,包括抑制亲食性细胞细胞素和酶,使其对治疗应用感兴趣,特别是对于关节炎和炎症等情况.此外,已经研究11-keto-beta-boyswellic酸的潜在抗癌特性,因为它可能在某些癌症细胞线上诱发流行性病,该物质一般在室温的固态中发现,在有机溶剂中可溶解.其安全特征和药性皮肤病学是正在进行的研究的主题,突出其作为天然治疗剂的潜力.总体而言,11-aketo-beta-boscellic酸是天然产品和医学化学领域的一个重要化合物.

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CAS号67416-61-9 3-O-乙酰基-11-氧代-β-乳香酸 | CAS号67416-61-9 3-O-乙酰基-11-氧代-β-乳香酸

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    专利信息


    专利号:US-2006234990-A1
    优先权日:1999-04-30
    标题 :Compositions of boswellic acids derived from Boswellia serrata gum resin, for treating lymphoproliferative and autoimmune conditions
    发明人:MAJEED MUHAMMED; BADMAEV VLADIMIR
    权利人:SAMI LABS LTD
    摘要:A method of treatment of lymphoproliferative and autoimmune disorders with a new composition of four boswellic acids including β-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-β-boswellic acid. Boswellic acids of invention have been obtained in a novel industrial process from the gum resin of Boswellia serrata tree, providing standardized composition which inhibits DNA, RNA and protein synthesis of the target cell without cytotoxic effects. The composition of invention provides advantage of irreversible cytostatic therapy, equivalent to biological effects of a cytotoxic therapy without killing body cells.

    专利号:WO-2008058514-A1
    优先权日:2006-11-14
    标 题:Preparations comprising boswellic acids for inhibiting the synthesis of prostaglandin e2
    发明人:WERZ OLIVER; SIEMONEIT ULF
    权利人:UNIV EBERHARD KARLS; WERZ OLIVER; SIEMONEIT ULF
    摘要:The present invention relates to the use of preparations with pentacyclic triterpenoic acids and structural derivatives thereof, in particular boswellic acids from Boswellia species (such as B. serrata, B. carterii, B. sacra), for inhibiting the inducible mitochondrial prostaglandin E2 synthase-1. In addition, the invention relates to the use of pentacyclic triterpenoic acids and derivatives thereof for producing a medicament for the treatment of PGE2-mediated diseases.

    专利号:WO-02085921-A2
    优先权日:2001-03-01
    标 题 :Simple method for the synthesis of boswellic acids and derivatives thereof

    专利号:DE-102006053475-A1
    优先权日:2006-11-14
    标题:Preparations for the inhibition of prostaglandin E2 synthesis

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    合成参考文献


    参考文献:10.1016/j.bmcl.2007.04.034
    摘要:Singh S, Khajuria A, Taneja SC, Khajuria RK, Singh J, Qazi GN. Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats. Bioorganic & Medicinal Chemistry Letters. 2007 Jul;17(13):3706–11. doi: 10.1016/j.bmcl.2007.04.034.
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