CAS: 134-50-9; Acridin-9-Amine Hydrochloride

该化合物是一种含有分子式C13H10N2-HCl的七环有机化合物,它是丙烯的衍生物,在9位置上有一个矿质组,由于具有很强的核酸的相互调和特性,通常用作荧光染色和生物污点.盐盐形式增强了其在水溶液中的溶解性,使之适合分子生物学和宗化学的应用.紫外线下的荧光使其得以用于DNA检测和可视化.该化合物还被用于涉及诱变性研究的研究,并作为有机合成的前体.由于它的潜在毒性,建议进行适当处理.

结构式图片

相似化合物

65944-23-2 90-45-9 952-23-8

欧盟法规

ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-4267234-A
    优先权日:1978-03-17
    标题:Polyglutaraldehyde synthesis and protein bonding substrates
    发明人:REMBAUM ALAN
    权利人:CALIFORNIA INST OF TECHN
    摘要:Polyglutaraldehyde (PGL) is polymerized in aqueous base or in aqueous highly polar solvent basic media to prepare powders, castable films or coatings for substrates such as amine substituted microbeads. PGL microspheres can be prepared by suspension polymerization in presence of a surfactant or by precipitating PGL from solution containing surfactant. Magnetic PGL microspheres are formed by suspension polymerization in the presence of magnetic particles such as iron oxide. Polyglutaraldehyde can be converted to a fluorescent polymer by reaction with m-aminophenol or other reagent. Proteins can be readily covalently bound to the polyglutaraldehyde.

    专利号:US-4369226-A
    优先权日:1979-03-19
    标 题:Polyglutaraldehyde synthesis and protein bonding substrates
    发明人:REMBAUM ALAN
    权利人:CALIFORNIA INST OF TECHN
    摘要:Polyglutaraldehyde (PGL) is polymerized in aqueous base or in aqueous highly polar solvent basic media to prepare powders, castable films or coatings for substrates such as amine substituted microbeads. PGL microspheres can be prepared by suspension polymerization in presence of a surfactant or by precipitating PGL from solution containing surfactant. Magnetic PGL microspheres are formed by suspension polymerization in the presence of magnetic particles such as iron oxide. Polyglutaraldehyde can be converted to a fluorescent polymer by reaction with m-aminophenol or other reagent. Proteins can be readily covalently bound to the polyglutaraldehyde.

    专利号:US-9907753-B2
    优先权日:2010-03-19
    标 题 :Lipid vesicle compositions and methods of use
    发明人:IRVINE DARRELL J; MOON JAEHYUN
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:US-9427406-B2
    优先权日:2012-04-13
    标 题:Sustained-release formulation
    发明人:GAVRYUSHIN ANDREY; KOBLER JOHANNES; SAUER JUERGEN
    权利人:NANOSCAPE AG; NAUTILUS CAPITAL CORP
    摘要:A substantially monodisperse assemblage of particles 10 having interconnected pores 20 and a core 30 with at least one shell 40, 60 disposed about the core 30 as well as a method for their synthesis is disclosed.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Cerón-Carrasco JP, Ruiz J, Vicente C, de Haro C, Bautista D, Zúñiga J, Requena A. DFT Simulation of Structural and Optical Properties of 9-Aminoacridine Half-Sandwich Ru(II), Rh(III), and Ir(III) Antitumoral Complexes and Their Interaction with DNA. J Chem Theory Comput. 2017 Aug 8;13(8):3898-3910. doi: 10.1021/acs.jctc.7b00139. Epub 2017 Jul 6. doi: 10.1016/j.bmc.2017.05.034. Epub 2017 May 19. doi: 10.1093/ageing/afx045. doi: 10.1016/j.aca.2017.01.043. Epub 2017 Jan 31. doi: 10.1124/mol.116.105874. Epub 2016 Nov 30. doi: 10.1016/j.bmc.2016.08.011. Epub 2016 Aug 8. doi: 10.1038/nprot.2016.081. Epub 2016 Jul 14. doi: 10.1093/toxsci/kfw039. Epub 2016 Feb 28. doi: 10.1016/j.ab.2016.02.004. Epub 2016 Feb 11. doi: 10.1093/chromsci/bmv170. Epub 2015 Dec 15.
    12: Ferguson DM, Jacobson BA, Jay-Dixon J, Patel MR, Kratzke RA, Raza A. Targeting Topoisomerase II Activity in NSCLC with 9-Aminoacridine Derivatives. Anticancer Res. 2015 Oct;35(10):5211-7. doi: 10.1177/1533317515603115. Epub 2015 Sep 17. doi: 10.1016/j.mrgentox.2015.06.005. Epub 2015 Jun 15. doi: 10.1016/j.mrgentox.2015.04.001. Epub 2015 Apr 8. doi: 10.1016/j.bios.2015.04.093. Epub 2015 Apr 30. doi: 10.1093/carcin/bgu220. Epub 2014 Oct 24. doi: 10.1080/09168451.2014.910102. Epub 2014 May 15. doi: 10.1039/c4ob00559g.

    合成参考文献


    摘要:KOCAN RM ET AL; IN VITRO TOXICITY OF EIGHT MUTAGENS/CARCINOGENS FOR THREE FISH CELL LINES; BULL ENVIRON CONTAM TOXICOL 23(1-2) 269 (1979)
    摘要:Department of Health & Human Services/National Institute of Environmental Health Sciences, National Toxicology Program; Reproduction and Fertility Assessment of 9-Aminoacridine Hydrochloride (CAS# 134-50-9) in CD-1 Mice When Administered in Feed, NTP Study No. RACB84042 (December 1985)
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知