CAS: 1239460-83-3; 5-Bromothieno[2,3-D]Pyrimidin-4(3H)-One
该化合物是一种七相循环化合物,其特点是三二基丙胺酮核心,在5号位置具有溴替代物.这种结构具有适合进一步功能化的回动性,使其成为医药化学和材料科学的宝贵中间体.它的引信环系系统有助于稳定,同时允许多种衍生,特别是生物活性分子的合成.溴原子在相互交织的反应中,如铃木或布奇瓦尔德-哈特维格的交织中提高了其效用,便利了复杂建筑的建造.由于敏感性,该化合物通常在受控制的条件下处理.其纯度和定义明确的结构支持研究应用的再生化.
- 英文名称5-Bromothieno[2,3-D]Pyrimidin-4(3H)-One
- 中文名称5-溴噻吩并[2,3-D]嘧啶-4(3H)-酮
- IUPAC名称5-bromothieno[2,3-d]pyrimidin-4(3H)-one
- 其它别名5-Bromothieno[2,3-D]Pyrimidin-4-Ol; 5-Bromothieno[2,3-D]Pyrimidin-4(1H)-One; 5-Bromo-3H-Thieno[2,3-D]Pyrimidin-4-One; Thieno[2,3-D]Pyrimidin-4(1H)-One, 5-Bromo- 95; Thieno[2,3-D]Pyrimidin-4(1H)-One, 5-Bromo-
- CAS编号1239460-83-3
- MFCD编号:MFCD25542166
- 分子式:C6H3BrN2OS分子量:231.07
- 产品CID: 344190
- 产品分类医药中间体
物理性质
上下游产品
5,6-Dibromothieno[2,3-D]Pyrimidin-4(3H)-One 1239460-82-2噻吩并[2,3-D]嘧啶-4(3H)-酮 Thieno[2,3-D]Pyrimidin-4(3H)One 14080-50-3
合成工艺路线路线简述
📜2-氨基噻吩-3-甲腈置于硫酸,溴,Sodium Acetate,溶剂黄146,锌体系中,用 水,溶剂黄146 用作溶剂,化学反应 0.25H,反应生成5-溴噻吩并[2,3-D]嘧啶-4(3H)-酮
参考文献:Design And Synthesis Of Brain Penetrant Selective Jnk Inhibitors With Improved Pharmacokinetic Properties For The Prevention Of Neurodegeneration
标题:Design And Synthesis Of Brain Penetrant Selective Jnk Inhibitors With Improved Pharmacokinetic Properties For The Prevention Of Neurodegeneration
摘要:The Sar Of A Series Of Brain Penetrant,Trisubstituted Thiophene Based Jnk Inhibitors With Improved Pharmacokinetic Properties Is Described. These Compounds Were Designed Based On Information Derived From Metabolite Identification Studies Which Led To Compounds Such As 42 With Lower Clearance,Greater Brain Exposure And Longer Half Life Compared To Earlier Analogs. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2011.06.100
