CAS: 1142223-08-2; (S)-Methyl 3-Cyclopropyl-3-(3-Hydroxyphenyl)Propanoate

英文名称(S)-Methyl 3-Cyclopropyl-3-(3-Hydroxyphenyl)Propanoate
中文名称(3S)-3-环丙基-3-(3-羟基苯基)丙酸甲酯
IUPAC名称methyl (S)-3-cyclopropyl-3-(3-hydroxyphenyl)propanoate
其它别名(S)-甲基 3-环丙基-3-(3-羟基苯基)丙酯; Methyl (S)-3-Cyclopropyl-3-(3-Hydroxyphenyl)Propanoate
CAS编号1142223-08-2
MFCD编号:MFCD27956898
分子式:C13H16O3分子量:220.27
产品CID: 175894
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: PXBFBXFVUPMAJK-LBPRGKRZSA-N
InChI=1S/C13H16O3/c1-16-13(15)8-12(9-5-6-9)10-3-2-4-11(14)7-10/h2-4,7,9,12,14H,5-6,8H2,1H3/t12-/m0/s1
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数4.0

相似化合物

1623144-99-9 1142224-62-1 1142223-06-0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319
防范说明P264-P270-P280-P302+P352-P330-P362+P364-P501

上下游产品

methyl (E)-3-cyclopropylpropenoate 3-hydroxyphenylboronic acid 5-((3-hydroxyphenyl)methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 5-(cyclopropyl(3-hydroxyphenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione [3H]-AM 1638 34H37FO4C34H37FO4 (S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate

合成工艺路线路线简述

合成目标产物 Benzenepropanoic Acid, β-Cyclopropyl-3-Hydroxy-, Methyl Ester, (βs)- 主要起始原料 3-Hydroxybenzaldehyde
1142224-62-1 = 1142223-08-2 + 1142223-06-0 [标题:Reaction Conditions
标题:Design And Synthesis Of Novel,Selective Gpr40 Agopams
作者:Plummer,Christopher W.; Clements,Matthew J.; Chen,Helen; Rajagopalan,Murali; Josien,Hubert; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2017 卷标:8(2) 页码:221-226]

1142224-62-1 = 1142223-08-2 + 1142223-06-0 [标题:Reaction Conditions
标题:Discovery Of Am-1638: A Potent And Orally Bioavailable Gpr40/ffa1 Full Agonist
作者:Brown,Sean P.; Dransfield,Paul J.; Vimolratana,Marc; Jiao,Xianyun; Zhu,Liusheng; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2012 卷标:3(9) 页码:726-730

📜间羟基苯甲醛置于硫酸体系中,用四氢呋喃,乙醇,正己烷,水,N,N-二甲基甲酰胺用作溶剂,化学反应 15.0H,反应生成(3S)-3-环丙基-3-(3-羟基苯基)丙酸甲酯
参考文献: Antidiabetic Compounds And Compositions[fr] Composes Antidiabétiques Et Compositions
标题: Antidiabetic Compounds And Compositions[fr] Composes Antidiabétiques Et Compositions
摘要:Provided Herein Are Novel Compounds (E.G.,Formula I,Ii,Ii-B,Iii,Or Iii-B),Pharmaceutical Compositions,And Methods Of Using Related To Gpr40. The Compounds Herein Are Typically Gpr40 Agonists,Which Can Be Used For Treating A Variety Of Disorders,Conditions Or Diseases Such As Type 2 Diabetes.