CAS: 1003-32-3; Thiazole-5-Carboxyaldehyde

相似化合物

38585-74-9 14527-41-4 14527-44-7

上下游产品

CAS号139669-95-7 2,4-二溴噻唑-5-甲醛 | CAS号92972-48-0 2,4-二氯噻唑-5-甲醛 | CAS号4394-85-8 N-甲酰吗啉 | CAS号116045-56-8 2-(trimethylsil... | CAS号38585-74-9 5-羟甲基噻唑 | CAS号38585-74-9 5-羟甲基噻唑 | CAS号238749-53-6 4H-吡咯并[2.3-d][1...

2-(三甲基甲硅烷基)噻唑-5-甲醛置于盐酸体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,反应生成5-噻唑甲醛
参考文献:A New Convenient Preparation Of 2-,4-,And 5-Thiazolecarboxaldehydes And Their Conversion Into The Corresponding Carbonitrilen-Oxides: Synthesis Of 3-Thiazolylisoxazoles And 3-Thiazolylisoxazolines
标题:A New Convenient Preparation Of 2-,4-,And 5-Thiazolecarboxaldehydes And Their Conversion Into The Corresponding Carbonitrilen-Oxides: Synthesis Of 3-Thiazolylisoxazoles And 3-Thiazolylisoxazolines
摘要:标题醛类化合物通过淬灭2-锂噻唑,4-锂-和5-锂-2-三甲基硅基噻唑与n-甲酰吗啉来制备,产率较高.在后两种情况下,随后进行脱硅化处理.这些醛类化合物通过其肟和羟肟酰氯转化为氰化物,与烯烃和乙炔二极亲电试剂反应,以中等至非常好产率得到3-噻唑基异恶唑啉和3-噻唑基异恶唑.
Doi:10.1055/s-1987-28146

专利信息

专利号:WO-9746543-A1
优先权日:1996-05-31
标题:Acetyl derivatives of thiazoles and analogues
发明人：PYNE STEPHEN GEOFFREY; UNG ALISON THAVARY
权利人:UNIV WOLLONGONG; PYNE STEPHEN GEOFFREY; UNG ALISON THAVARY
摘要:The present invention is directed to compounds useful in the treatment of autoimmune diseases and inflammatory diseases of general formula (I) wherein R1 is alkyl, alkenyl or alkynyl having from 1 to 6 carbons, phenyl, benzyl or phenethyl; R2 is H, C1 to C5 alkyl which can optionally be partially hydroxylated or the group (a) wherein n is from 0 to 4; and X, Y and Z are independently CH, N, NH, O or S, or a pharmaceutically acceptable ester or acid addition salt thereof, or a stereoisomer or a geometric isomer thereof, with the proviso that at least one of X, Y or Z is CH, that one and only one of X, Y and Z is NH, O or S and further that when Y is N or NH then Z is not N or NH. The present invention is also concerned with processes for the synthesis of the compounds and with methods of use of the compounds.

专利号:US-2024002405-A1
优先权日:2022-06-01
标题 :Antimicrobial compounds, synthesis methods, and uses thereof
发明人：VERMA RAJNI; DONAVALLI KRISHNA MOHAN; ZAID GENE H
权利人:ANKH LIFE SCIENCES LTD
摘要:Fused tricyclic compounds and novel methods of synthesizing, using, and/or administering the same. Methods of inhibiting microbial activity and/or treating a microbial infection with fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds. The treatment of subjects suffering from a microbial infection comprises the step of administering to the subject one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds or a composition comprising one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds.

专利号:US-6852711-B2
优先权日:1998-09-11
标题:HIV protease inhibitors
发明人：BOYER JR FREDERICK EARL; DOMAGALA JOHN MICHAEL; ELLSWORTH EDMUND LEE; GAJDA CHRISTOPHER ANDREW; HAGEN SUSAN ELIZABETH; LOVDAHL MICHAEL JAMES; LUNNEY ELIZABETH ANN; MARKOSKI LARRY JAMES; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:AGOURON PHARMA
摘要:The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

专利号:WO-2008153870-A1
优先权日:2007-06-07
标题 :Synthesis of substituted-3-aminopyrazoles

专利号:US-2012029204-A1
优先权日:2007-06-07
标 题 :Synthesis of substituted-3-aminopyrazoles

专利号:CN-117603202-A
优先权日:2023-11-16
标 题:Synthesis method of pyrrolidine derivative substituted by 2-nitrogen heterocycle