CAS: 95713-52-3; (S)-2-((5-Fluoro-2,4-Dinitrophenyl)Amino)Propanamide

上下游产品

1,5-difluoro-2,4-dinitrobenzene (S)-alaninamide hydr°Chloride L-alanine amide D-alaninamide L-FDAA-L-Pro L-FDAA-D-leucine

📜L-丙氨酰胺,1,5-二氟-2,4-二硝基苯置于magnesium Sulfate,Sodium Hydroxide体系中,用 水,丙酮 作为反应溶剂,化学反应 3.5H,以57%的收率获得产物n-A-(2,4-二硝基-5-氟苯基)-L-丙氨酸
参考文献:钯介导的交叉偶联催化多肽和蛋白质中脱氢丙氨酸的催化修饰
标题:钯介导的交叉偶联催化多肽和蛋白质中脱氢丙氨酸的催化修饰
摘要:脱氢丙氨酸(dha)是一种非常通用的非规范氨基酸,通常在抗菌肽中发现.本文中,我们介绍了通过钯介导的交叉偶联反应对dha的催化修饰.通过使用pd(edta)(oac)2作为水溶性催化剂,多种芳基硼酸与蛋白质和多肽(如乳链菌肽)中的脱水残基偶联.交叉偶联反应既产生了保留了α-碳的sp 2-杂化的heck产物,也产生了共轭加成产物.该反应可在温和的水性条件下进行,这使该方法成为生物正交催化方法的一个有吸引力的补充.
DOI:10.1002/chem.201802846

专利信息

专利号:US-12421534-B2
优先权日:2021-11-10
标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs
发明人：ALMHJELL PATRICK J; ARNOLD FRANCES H
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.

专利号:WO-9707129-A1
优先权日:1995-08-18
标题 :Solution synthesis of peripheral acting analgesic opioid tetrapeptides
发明人：RINALDI NICHOLAS
权利人:IAF BIOCHEM INT; RINALDI NICHOLAS
摘要:This invention provides a bulk scale process for the solution synthesis of enantiomerically pure peripherally acting analgesic opioid tetrapeptides corresponding to formula (I): Tyr-(D)R1-R2-R3-NH2, where R1 is Ala or Arg; R2 is Phe or Phe(p-F); and R3 is Phe or Phe(p-F). A new and unique multi-step process is disclosed comprising the joining of two dipeptides using standard solution phase synthesis techniques, but adjusting the individual factors (e.g., solvents, activating agents, neutralizing agents etc.), to minimize racemization of the second amino acid. Tremendous cost efficiencies are achieved due to elimination of traditional sequential blocking-deblocking cycles and multiple chromatographic purification steps, which also enables these simple kilogram quantity methods to be scaled up to commercial production.

专利号:WO-2012059797-A1
优先权日:2010-11-04
标题 :Process for synthesis of (s) - pregabalin
发明人：ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA
权利人:LUPIN LTD; ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA
摘要:Improved process for the synthesis of (S)-pregabalin having more than 99% ee through (S) 3-cyano-5-methyl-hexanoic acid has been developed. In addition to above, a novel process for resolution of ( RS ) - 3-cyano-5-methyl-hexanoic acid through diastereomeric salt formation with cinchonidine to obtain ( S ) - 3-cyano-5-methyl-hexanoic acid in high yield and high optical purity has been developed and furthermore process for recovery/ reuse of cinchonidine is also developed to improve the overall process efficiency.

专利号:US-5280093-A
优先权日:1989-06-29
标题 :Chiral polymers for the synthesis of pure enantiomers of amino acids
发明人：JACQUIER ROBERT; CALMES MONIQUE; DAUNIS JACQUES
权利人:RHONE POULENC CHIMIE
摘要:The present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion. n These polymers are characterized in that they comprise: n a chiral unit n a functionalizing unit n an optional crosslinking unit n Application to chiral organic synthesis.

专利号:US-2022372533-A1
优先权日:2017-06-30
标 题 :Transgenic microorganisms and synthesis of piperazic acid, piperazic acid containing products, and derivatives thereof
发明人：VAN DYKE-BLODGETT JOSHUA; HU YIFEI
权利人:VAN DYKE BLODGETT JOSHUA; HU YIFEI; WASHINGTON UNIVERSITY ST LOUIS
摘要:Among the various aspects of the present disclosure is the provision of a biological and biochemical production of piperazic acid derived from the newly discovered production pathway for L-piperazic acid. One aspect of the present disclosure includes a transgenic microorganism (e.g., bacteria) engineered to accumulate piperazic acid and derivatives thereof, including a piperazic acid (Piz)-containing product. Another aspect of the present disclosure includes biochemical and biological methods for producing piperazic acid and derivatives thereof, including a piperazic acid (Piz)-containing product. Another aspect of the present disclosure includes compositions and methods of using isotopically labeled piperazic acid and derivatives thereof, including a piperazic acid (Piz)-containing product.

专利号:US-2025034607-A1
优先权日:2021-12-03
标题 :Process of Synthesizing (R)-3-aminobutan-1-ol
发明人：BOBKO MARK; FUERST DOUGLAS; MORGAN CHRISTOPHER
权利人:VIIV HEALTHCARE CO
摘要:The present invention relates to an aminotransaminase useful in the synthesis of (R)-3-aminobutan-1-ol (RABO). The present invention also provides a process of preparing (R)-3-aminobutan-1-ol (RABO) with the disclosed aminotransaminase.