CAS: 937648-82-3; 3-Methylpicolinamide

该化合物其结构特征为3-甲基丙醇南化物,包括一个以甲基组和氨化功能组替代的环,该化合物通常具有芳香和氨化物功能的特性,例如极地溶剂中的中溶性以及由于氨化物组而具有的潜在氢联结能力;该甲基组的存在可影响其反应性和消毒特性,使其成为各种化学应用,包括医药化学和材料科学中感兴趣的一个主题;此外,3-甲基丙醇南化物可能展示生物活动,可以探索这些生物活动用于潜在的制药应用;其分子相互作用,稳定性和再活性可受到诸如pH和温度等环境因素的影响;与许多有机化合物一样,应参考安全数据,以了解其处理和潜在危害.

结构式图片

相似化合物

20970-75-6 153936-26-6 357288-02-9

物理性质

MSDS等安全信息

上下游产品

2-cyano-3-methylpyridine 3-Methylpyridine formamide 3-methylpyridin-2-ylamine

合成工艺路线路线简述

  • 合成目标产物 3-Methylpicolinamide 主要起始原料 3-Methylpicolinonitrile
  • 20970-75-6 = 937648-82-3
    反应条件:1.1 Reagents: Sulfuric Acid; 25 Min,80 °C; 80 °C -> Rt1.2 Reagents: Sodium Carbonate Solvents: Water; Ph 7
    标题:Preparation Of Piperidine Derivatives For Use As Orexin Receptor Antagonists
    参考文献:World Intellectual Property Organization]

    3430-17-9 + 14459-95-1 = 937648-82-3
    反应条件:1.1 Catalysts: Di-μ-Chlorobis(η3-2-Propenyl)Dipalladium,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: 1,4-Dioxane,Water; 18 H,95 - 105 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 3 H,35 - 45 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 7 - 8
    标题:One-Pot Preparation Method Of Aryl Primary Amide By Palladium Metal Catalysis
    参考文献:China]

    20970-75-6 = 937648-82-3
    反应条件:1.1 Reagents: Sodium Hydroxide,Manganese Oxide (Mno2) Solvents: Acetone,Water; 3.5 H,Rt -> 70 °C
    标题:Preparation Of 3-Methyl-2-Formylaminopyridine Using Mno2 As An Oxidation Mediator
    作者:Wang,Yan-Hong; Chen,Ri-Yao; Zheng,Xi; Chen,Xiao; Chen,Zhen
    参考文献:Fujian Shifan Daxue Xuebao 日期:2008 卷标:24(2) 页码:54-56]

    75-12-7 = 937648-82-3 + 20970-77-8
    反应条件:1.1 Reagents: Potassium Persulfate; 12 H,70 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water
    标题:Transition-Metal-Free Synthesis Of Primary To Tertiary Carboxamides: A Quick Access To Prodrug-Pyrazinecarboxamide
    作者:Mete,Trimbak B.; Singh,Ankit; Bhat,Ramakrishna G.
    参考文献:Tetrahedron Letters 日期:2017 卷标:58(50) 页码:4709-4712]

    20970-75-6 = 937648-82-3
    反应条件:1.1 Reagents: Sulfuric Acid; 25 Min,80 °C; 80 °C -> Rt1.2 Reagents: Sodium Carbonate Solvents: Water; Ph 7
    标题:Substituted Pyrrolidines And Piperidines As Orexin Receptor Antagonists And Their Preparation
    参考文献:World Intellectual Property Organization]

    20970-75-6 = 937648-82-3
    反应条件:1.1 Reagents: Aldoxime Catalysts: Nickel Dichloride Solvents: Water; 3 H,Reflux
    标题:The Hydration Of Nitriles Catalyzed By Simple Transition Metal Salt Of The Fourth Period With The Aid Of Acetaldoxime
    作者:Ma,Xiaoyun; He,Ying; Wang,Pengcheng; Lu,Ming
    参考文献:Applied Organometallic Chemistry 日期:2012 卷标:26(7) 页码:377-382]

    20970-75-6 = 937648-82-3
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Acetone,Water; 15 Min,Rt; Rt -> 50 °C; 3.5 H,50 °C
    标题:Preparation Of 3-Methyl-2-Pyridinamine
    参考文献:China]

    20970-75-6 = 937648-82-3
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Acetone,Water; 15 Min,Rt; Rt -> 50 °C; 3.5 H,50 °C
    标题:New Synthetic Method Of 2-Amino-3-Methylpyridine
    作者:Li,Xiaojuan; Dai,Liyan; Wang,Xiaozhong; Chen,Yingqi
    参考文献:Huaxue Shijie 日期:2006 卷标:47(2) 页码:105-107]

    20970-75-6 = 937648-82-3
    反应条件:1.1 Reagents: Aldoxime Catalysts: Sodium Molybdate (Na2Moo4) Dihydrate Solvents: Water; 16 H,Rt -> Reflux
    标题:Efficient Mo(Vi)-Catalyzed Hydration Of Nitrile With Acetaldoxime
    作者:Ma,Xiaoyun; He,Ying; Lu,Ming
    参考文献:Synthetic Communications 日期:2014 卷标:44(4) 页码:474-480]

    20970-75-6 = 937648-82-3
    反应条件:1.1 Reagents: Sodium Hydroxide,Manganese Oxide (Mno2),Sodium Sulfate Solvents: Acetone,Water; 70 °C
    标题:Electro-Oxidized Preparation Of 3-Methyl-2-Formyl-Amino Pyridine By Bipolar Membrane
    作者:Wang,Yan-Hong; Ma,Xiu-Ling; Chen,Ri-Yao; Zheng,Xi; Chen,Zhen
    参考文献:Wuli Huaxue Xuebao 日期:2008 卷标:24(6) 页码:1041-1046]

    20970-75-6 = 937648-82-3
    反应条件:1.1 Catalysts: Manganese Oxide (Mno2),Ruthenium Solvents: Water; 2 H,60 °C
    标题:An Efficient Hydration Of Nitriles With Ruthenium-Supported Heterogeneous Catalyst In Water Under Moderate Conditions
    作者:Hussain,Muhammad Asif; Choi,Eun Ju; Maqbool,Adnan; Atif,Muhammad; Zeb,Hassan; Et Al
    参考文献:Journal Of Industrial And Engineering Chemistry (Amsterdam 日期:2021 卷标:99 页码:187-195
📜2-氰基-3-甲基吡啶置于乙醛肟,Sodium Molybdate Dihydrate体系中,用 水 作为反应溶剂,化学反应 16.0H,以77%的收率获得产物3-甲基吡啶-2-甲酰胺
参考文献:Mo(Vi)-催化腈与乙醛肟的高效水合
标题:Mo(Vi)-催化腈与乙醛肟的高效水合
摘要:摘要 描述了一种使用市售的乙醛肟和廉价的金属氧酸盐(如钼酸盐,钒酸盐和钨酸盐)在环保水中选择性水合腈成酰胺的方法.根据该协议,包括芳族腈,杂环腈和脂肪族腈在内的腈以非常好到极好的收率转化为相应的酰胺.[本文提供补充材料.访问出版商的 Synthetic Communications® 在线版,获取以下免费补充资源:完整的实验和光谱细节.] 图形摘要
DOI:10.1080/00397911.2013.806668

海关参考信息

专利信息


专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-9771379-B2
优先权日:2015-09-24
标题:N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nwherein the variables R 1 , R 2 , R 3 , R 4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-102803222-A
优先权日:2010-03-18
标 题:A method and process for the synthesis and production of deuterated ω-diphenylurea

专利号:BR-112012009751-A2
优先权日:2009-10-26
标题:methods of synthesis and purification of heteroaryl

专利号:PH-12014500392-B1
优先权日:2009-10-26
标题:Methods of synthesis and purification of heteroaryl compounds

专利号:CN-105001225-B
优先权日:2011-03-08
标题:Heterocyclic regulators of lipid synthesis

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合成参考文献


参考文献:10.1007/978-1-59259-947-9_4
摘要:ElSohly HN, ElSohly MA. Marijuana Smoke Condensate. 2007. In: Marijuana and the Cannabinoids. : Humana Press; 2007.
参考文献:10.1007/bf02280375
摘要:Novotny M, Merli F, Wiesler D, Saeed T. Composition of the basic fraction of marijuana and tobacco condensates: A comparative study by capillary GC/MS. Chromatographia. 1982 Sep;15(9):564–8. doi: 10.1007/bf02280375.
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