CAS: 90280-13-0; 2-[bis(4-Fluorophenyl)Methylsulfinyl]Acetamide

上下游产品

2-(Bis(4-Fluorophenyl)Methylthio)Acetamide 90280-20-9
{[双（4-氟苯基）甲基]硫基}乙酸 2-((Bis(4-Fluorophenyl)Methyl)-Thio)Acetic Acid 90212-81-0
Methyl [[bis-(4-Fluorophenyl)Methyl]Thio]Acetate 90212-82-1

📜4,4'-二氟二苯甲醇置于甲醇,Ammonium Hydroxide,双氧水,Potassium Carbonate,氯化铵,溶剂黄146,三氟乙酸体系中,用 甲醇,水,丙酮 作为反应溶剂,化学反应 100.0H,反应生成 2-[[二(4-氟苯基)甲基]亚磺酰]乙酰胺
参考文献:新型系列莫达非尼(2-[((二苯甲基)亚磺酰基]乙酰胺)类似物在单胺转运蛋白上的结构-活性关系.
标题:新型系列莫达非尼(2-[((二苯甲基)亚磺酰基]乙酰胺)类似物在单胺转运蛋白上的结构-活性关系.
摘要:合成了一系列莫达非尼(1)类似物,其中1)将对卤代取代基添加到芳环上,2)除去亚砜官能团,3)伯酰胺基被仲和叔酰胺和胺取代,得到研究这些化学修饰对dat,Sert和net结合的影响.另外,将(+/-)-莫达非尼(1),其r-和s-对映异构体及其对氯亚磺酰基乙酰胺类似物(5C)对小鼠的运动刺激作用与可卡因进行了比较.
DOI:10.1021/ml1002025

专利信息

专利号:US-10456387-B2
优先权日:2011-11-29
标 题:Phacetoperane for treating of attention deficit hyperactivity disorder
发明人：KONOFAL ERIC; FIGADERE BRUNO
权利人:NLS PHARMA AG; NLS PHARMACEUTICS AG
摘要:The invention relates to the treatment of an attention deficit hyperactivity disorder (ADHD) with alpha-phenyl(piperidin-2-yl)methanol, or the pharmaceutically acceptable salts and esters thereof, in particular the acetate derivative, more particularly dextrophacetoperane. The invention additionally provides a method of synthesis of the (S,S) enantiomer of alpha-phenyl(piperidin-2-yl)methanol as well as a method of synthesis of dextrophacetoperane.

专利号:US-2024342119-A1
优先权日:2021-08-02
标 题:Composition for treating hypertrophic scars and keloids comprising benzhydryl thioacetamide compound as active ingredient
发明人：KIM SEONG-JIN; KIM SEON-MYUNG
权利人:CELLIONBIOMED INC
摘要:The present invention relates to a composition for treating hypertrophic scars and keloids, comprising a benzhydryl thioacetamide compound as an active ingredient. The benzhydryl thioacetamide compound inhibits cell proliferation and an increase in intracellular Ca 2+ concentration, in fibroblasts, keratinocytes and vascular endothelial cells that are involved in skin fibrosis, and inhibits the synthesis of collagen, which is the extracellular matrix, and thus has the effect of effectively treating intractable hypertrophic scars and keloids.