CAS: 84956-71-8; 2-(Tert-Butyl)-4,5-Dichloropyridazin-3(2H)-One

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📜叔丁基肼盐酸盐 以 甲醇 作为反应溶剂,化学反应生成 哒嗪酮
参考文献:Prostaglandin Endoperoxide H Synthase Biosynthesis Inhibitors
标题:Prostaglandin Endoperoxide H Synthase Biosynthesis Inhibitors
摘要:该发明描述了式i的吡啶并酮化合物,这些化合物是环氧合酶(cox)抑制剂,特别是选择性地抑制环氧合酶-2(cox-2).cox-2是与炎症相关的可诱导异构体,与构成性异构体环氧合酶-1(cox-1)相对,后者是许多组织中重要的"基础"酶,包括胃肠道(gi)和肾脏.这些化合物对cox-2的选择性减少了目前市售的非甾体类抗炎药(nsaids)所见到的不良胃肠道和肾脏副作用.

专利信息

专利号:US-9603951-B2
优先权日:2010-02-08
标题 :Methods and apparatus for synthesizing imaging agents, and intermediates thereof
发明人：LAZEWATSKY JOEL; DEVINE MARYBETH
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18 F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-2018318456-A1
优先权日:2012-08-10
标题:Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:US-2020230264-A1
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:WO-2014026079-A2
优先权日:2012-08-10
标题 :Compositions, methods, and systems of the synthesis and use of imaging agents

专利号:CN-104718193-A
优先权日:2012-08-10
标题 :Compositions, methods, and systems for synthesis and use of contrast agents