CAS: 79479-07-5; (2S,3R)-Methyl 2-((Tert-Butoxycarbonyl)Amino)-3-Hydroxybutanoate

相似化合物

2592-18-9 39994-75-7 55674-67-4

上下游产品

diazomethane B°C-Thr-OH N-(t-Butyloxycarbonyl)-L-threonine tert-butyl dicarbonatedi-tert-butyl dicarbonate(2S,3R)-3-[Bis-(4-chloro-benzyloxy)-phosphanyloxy]-2-tert-butoxycarbonylamino-butyric acid methyl ester methyl 2-(N-(1,1-dimethylethoxy)methanamido)butenoate (Z)-methyl 2-((tertbutoxycarbonyl)amino)but-2-enoate (E)-2-N-(tert-butyloxycarbonyl)dehydroaminobutyric acid methyl ester

Boc-L-Thr(Bn)-Ome置于氢气体系中,用 乙醇 作为反应溶剂,化学反应 0.83H,以100%的收率获得产物boc-苏氨酸甲酯
参考文献:聚氯乙烯负载的钯纳米粒子:快速氢化反应的催化剂†
标题:聚氯乙烯负载的钯纳米粒子:快速氢化反应的催化剂†
摘要:通过高效且廉价的方案制备了负载在聚氯乙烯基质(pvc-Pd 0)上的钯纳米颗粒.该催化剂已通过xrd,Sem和tem进行了表征,并证明了其在还原一系列官能团以及去除某些在肽化学中使用的常见保护基的实用性.
DOI:10.1039/c0Ob00962H

专利信息

专利号:US-9771377-B2
优先权日:2012-12-21
标 题 :Synthesis of FR901464 and analogs with antitumor activity
发明人：KOIDE KAZUNORI; OSMAN SAMI SAIF ELDIN ALI
权利人:UNIV OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
摘要:The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.

专利号:WO-9102739-A1
优先权日:1989-08-11
标题:Synthesis of glycosides having predetermined stereochemistry
发明人：DANISHEFSKY SAMUEL J
权利人:UNIV YALE
摘要:Methods of stereoselectively preparing a substituted 1,2-anhydrosugar wherein a substituted glycal is converted into a 1,2-anhydrosugar that is utilized to glycosylate a hydroxyl group containing glycal, are disclosed. Methods of preparing a saccharide multimer wherein a nucleophile is reacted with a substituted 1,2-anhydrosugar having a plurality of non-participating substituents, are disclosed. In addition, methods of preparing stereospecific halo-substituted saccharide multimers by haloglycosylation of a glycosyl donor substituted glycal and a glycosyl acceptor glycal derivative in the absence of water and in the presence of a halonium ion, are disclosed. Methods of preparing stereospecific particle-linked halo-substituted saccharide multimers, by haloglycosylation of a particle-linked nucleophilic hydroxyl group with a substituted glycal and a halonium ion, are also disclosed.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-8309599-B2
优先权日:2006-09-08
标题 :Synthesis of FR901464 and analogs with antitumor activity
发明人：KOIDE KAZUNORI; ALBERT BRIAN J; SIVARAMAKRISHNAN ANANTHAPADMANABHAN
权利人:KOIDE KAZUNORI; ALBERT BRIAN J; SIVARAMAKRISHNAN ANANTHAPADMANABHAN; UNIV PITTSBURGH
摘要:The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.

专利号:US-2008096879-A1
优先权日:2006-09-08
标题:Synthesis of fr901464 and analogs with antitumor activity

专利号:US-7825267-B2
优先权日:2006-09-08
标 题 :Synthesis of FR901464 and analogs with antitumor activity