CAS: 66270-97-1; 2-Oxo-2-Phenylethyl 2-(4-(Bromomethyl)Phenyl)Acetate

上下游产品

CAS号13737-36-5 4-(溴乙烷)苯乙酸 | CAS号70-11-1 2-溴苯乙酮 | CAS号622-47-9 对甲苯乙酸 | CAS号582-24-1 2-羟基苯乙酮

📜对甲基苯乙酸置于溴,三氟乙酸酐体系中,用 四氯化碳 作为反应溶剂,化学反应 28.0H,反应生成 4-(溴甲基)苯乙酸苯甲酰甲酯
参考文献:Synthesis Of α-Helices Having A Positively Charged Random Coil-Block On Either N-Or C-Terminal
标题:Synthesis Of α-Helices Having A Positively Charged Random Coil-Block On Either N-Or C-Terminal
摘要:为了研究电荷诱导的α螺旋稳定作用,我们合成了在螺旋 N 端或 C 端带有带正电荷的随机线圈块,长度严格限定的α螺旋肽--(Ala)20(X)20Phe 和 (X)20(Ala)20Phe (X=lys 或 Orn).成分二肽被耦合在对-(氧甲基)苯乙酰胺甲基聚苯乙烯上.
DOI:10.1246/bcsj.61.2467

专利信息

专利号:US-5021550-A
优先权日:1986-10-07
标 题 :Method for preventing deletion sequences in solid phase synthesis
发明人：ZEIGER ALLEN R
权利人:UNIV JEFFERSON
摘要:Improved methods for solid-state synthesis of polymers, especially polypeptides and polynucleotides, are provided. In accordance with a preferred embodiment, selectively activatable and reactive bonding moieties are covalently bonded to solid supports for polynucleotide and polypeptide syntheses. Products of failed reactions and some side products are caused to react with the selectively activatable and reactive bonding moiety to cause divalent bonding of unwanted products to the solid support. Upon cleavage of the initial situs of covalent bonding to the solid support, desired products are free to be collected while unwanted products remain covalently bonded to the support. Ease of purification of such polymers is a principal object of the present invention. The methods of the invention are amenable to automation and digital control and novel solid supports, activatable, reactive bonding moieties and other compositions are presented. The expression of polynucleotides prepared in accordance with preferred embodiments produces novel polypeptides.

专利号:US-5310894-A
优先权日:1990-09-11
标题 :Solid phase polynucleotide syntheses
发明人：ZEIGER ALLEN R
权利人:UNIV JEFFERSON
摘要:Methods for solid-state synthesis of polymers, especially polypeptides and polynucleotides, are provided. In accordance with a preferred embodiment, selectively activatable and reactive bonding moieties are covalently bonded to solid supports for polynucleotide and polypeptide syntheses. Products of failed reactions and some side products are caused to react with the selectively activatable and reactive bonding moiety to cause divalent bonding of unwanted products to the solid support. Upon cleavage of the initial situs of covalent bonding to the solid support, desired products are free to be collected while unwanted products remain covalently bonded to the support. Ease of purification of such polymers is a principal object of the present invention. The methods of the invention are amenable to automation and digital control and novel solid supports, activatable, reactive bonding moieties and other compositions are presented. The expression of polynucleotides prepared in accordance with preferred embodiments produces novel polypeptides.

专利号:EP-0863150-A1
优先权日:1997-02-08
标 题:A method for the preparation of nucleic acid binding compound
发明人：BATZ HANS-GEORG DR; HANSEN HENRIK FRYDENLUND; ORUM HENRIK DR; KOCH TROELS DR; KOFOED THOMAS
权利人:BOEHRINGER MANNHEIM GMBH
摘要:A method of the preparation of a nucleic acid binding compound is disclosed wherein a firstnprotecting group removable by a medium strong base and a second protecting groupnremovable by a medium strong acid are used. The synthesis is thereby is increased innrecovery yield of a nucleic acid binding compound prepared.

专利号:EP-1144414-B1
优先权日:1999-01-08
标 题 :Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
发明人：BAIRD ELDON E; DERVAN PETER B
权利人:CALIFORNIA INST OF TECHN
摘要:The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular units. At least one molecular unit of such a compound is a hydrogen bond donor or acceptor. The polymer portions are covalently linked to form a cycle. These compounds are capable of targeting specific nucleotide sequences in double-stranded nucleic acids, particularly double-stranded DNA. Accordingly, such compounds can be used to modulate, e.g., increase or decrease, the expression of one or more genes in vitro or in vivo.

专利号:WO-2008080988-A2
优先权日:2006-12-28
标题:Cyclopentanone derivatives, method of synthesis and uses thereof

专利号:EP-1939192-A1
优先权日:2006-12-28
标 题:Cyclopentanone derivatives, method of synthesis and uses thereof