,海藻糖 以 水,柠檬酸 作为反应溶剂,化学反应 32.33H,反应生成 D(+)-海藻糖二水合物 参考文献:Method For Non-Fry Cooking And Its Uses 标题:Method For Non-Fry Cooking And Its Uses 摘要:一种非油炸烹饪方法,包括以下步骤:使用相对较高温度和浓度的水溶性海藻糖溶液加热和脱水食材;制备出口感,味道,口味令人满意且几乎不含过多脂肪的非油炸食品;以海藻糖作为有效成分的非油炸烹饪剂.
专利号:US-4307229-A 优先权日:1979-11-07 标题:6,6'-Diesters of trehalose and process for the synthesis thereof 发明人:LIAV AVRAHAM; GOREN MAYER B 权利人:LIAV AVRAHAM; GOREN MAYER B 摘要:An improved process is described for synthesizing simple and complex 6,6'-diacyl esters of trehalose and intermediates useful therein. Novel 6,6'-diacyl esters of trehalose and novel intermediates useful in the process of the invention are also disclosed. The inventive process is capable of producing the desired compounds economically and in pure form from readily available starting materials.
专利号:US-10077458-B2 优先权日:2014-02-17 标题 :Microbiological process 发明人:ALVAREZ-RUIZ EMILIO; COLLIS ANDREW JOHN; DANN ALISON SARAH; FOSBERRY ANDREW PETER; READY SARAH JANE; VAZQUEZ MUNIZ MARIA JESUS 权利人:GLAXOSMITHKLINE IP DEV LTD 摘要:A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.
专利号:US-2025281418-A1 优先权日:2021-08-11 标题:Lipid nanoparticle formulations and methods of synthesis thereof 发明人:SMITH MICHAEL H 权利人:MODERNATX INC 摘要:Stabilized formulations of lipids and nucleic acids, including lipid nanoparticle formulations which encapsulate nucleic acids are disclosed herein. Methods of using the formulations are also provided.
专利号:US-2024043895-A1 优先权日:2022-08-08 标题:Spray dried extract 发明人:GETTEL DOUGLAS LEE; ZAWADA JAMES; KISS ROBERT DAVID; DWYER ALLISON; SINGH AMARJEET; JOHNSON RICHARD ALAN; PIERI LISA SAWICKI; Dowlatshahi Dara Patrick 权利人:SUTRO BIOPHARMA INC 摘要:This disclosure provides for an improved method of stabilizing spray-dried bacterial extracts with a composition comprising a stabilizer such that the extracts can be used in cell-free protein synthesis. Also provided herein are formulations for stable, spray-dried bacterial extracts that have increased protein synthesis activity compared to spray-dried bacterial extracts that do not contain a stabilizer.
专利号:US-9976131-B2 优先权日:2013-03-14 标 题 :Ribotoxin molecules derived from sarcin and other related fungal ribotoxins 发明人:GEHLSEN KURT R; JONES TIMOTHY DAVID; CARR FRANCIS JOSEPH; HEARN ARRON 权利人:RESEARCH CORPORATION TECH INC 摘要:The present application relates to modified T cell epitopes derived from fungal ribotoxins, including α-sarcin, clavin, gigantin, mitogillin, and restrictocin, as well as modified ribotoxin molecules comprising one or more of the modified epitopes. The modified ribotoxin molecules inhibit protein synthesis, like the wild type ribotoxins, but exhibit reduced immunogenicity as compared to the corresponding wild type ribotoxin. Another aspect relates to a fusion protein which comprises a modified ribotoxin fused or conjugated or otherwise linked to a targeting molecule that is effective for binding a target of interest. Another aspect relates to the use of the modified ribotoxin or fusion protein for treating or managing a disease or condition.
专利号:US-11001872-B2 优先权日:2015-09-22 标 题:Designing customized protein-specific buffer system 发明人:CLARK SHAWN 权利人:CLARK SHAWN 摘要:The present invention is related to the field of protein chemistry. In particular, mixed buffer compositions are formulated that allow an accurate identification of agent-induced changes in protein melting point temperatures. Such buffer compositions provide for methods that determine the specific effects of exogenous agents on protein stability, cryoprotective effects and/or protein quality control (e.g., synthesis and/or extraction purity validations).
参考文献:10.1007/s11095-009-0039-4 摘要:Ji JA, Liu J, Shire SJ, Kamerzell TJ, Hong S, Billeci K, Shen Y, Wang YJ. Characteristics of rhVEGF Release from Topical Hydrogel Formulations. Pharmaceutical Research. 2010 Feb 13;27(4):644–54. doi: 10.1007/s11095-009-0039-4.