CAS: 483-49-8; (+-)-Berbin

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    5,6,13,13A-Tetrahydro-8H-Dibenzo[a,G]Chinolizin-8-On 41173-73-3
    1-苄基-1,2,3,4-四氢异喹啉 1-Benzyl-1,2,3,4-Tetrahydroisoquinoline 19716-56-4

    合成工艺路线路线简述

      📜2-[(Trimethylsilyl)Methyl]Benzyl Alcohol置于四溴化碳,Silver Perchlorate,三苯基膦体系中,用 乙醚,乙腈 作为反应溶剂,化学反应生成 四氢原小蘖碱
      参考文献:Diradical Cyclization Methodologies. Model Studies Probing The Application Of Photoinduced-Electron Transfer Processes In Synthetic Routes To The Protoberberine And Spirobenzyl Isoquinoline Alkaloids
      标题:Diradical Cyclization Methodologies. Model Studies Probing The Application Of Photoinduced-Electron Transfer Processes In Synthetic Routes To The Protoberberine And Spirobenzyl Isoquinoline Alkaloids
      摘要:
      DOI:10.1016/s0040-4039(00)98248-0

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      专利信息


      专利号:US-9856251-B2
      优先权日:2008-09-03
      标题:Substituted berbines and processes for their synthesis
      发明人：WANG PETER X; MOSER FRANK W; CANTRELL GARY L; GROTE CHRISTOPHER W
      权利人:MALLINCKRODT LLC
      摘要:The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.

      专利号:US-9181237-B2
      优先权日:2013-10-04
      标 题 :Substituted berbines and their synthesis
      发明人：GROTE CHRISTOPHER W
      权利人:MALLINCKRODT LLC
      摘要:The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds, as well as intermediates used in the synthesis of substituted berbine compounds. Also provided are methods for using the substituted berbines to inhibit cancer cell growth.

      专利号:EP-3137618-A1
      优先权日:2014-04-29
      标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds

      专利号:US-2017058305-A1
      优先权日:2014-04-29
      标 题:Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

      专利号:US-2021198706-A1
      优先权日:2014-04-29
      标题 :Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

      专利号:WO-2015164960-A1
      优先权日:2014-04-29
      标 题:Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds

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      主要参考文献

      参考标题:Substituted Berbines And Their Synthesis
      摘要:The Present Invention Provides Substituted Berbines, Processes For The Synthesis Of Substituted Berbine Compounds, As Well As Intermediates Used In The Synthesis Of Substituted Berbine Compounds. Also Provided Are Methods For Using The Substituted Berbines To Inhibit Cancer Cell Growth.

      合成参考文献


      参考文献:10.1016/j.bmcl.2017.01.090
      摘要:Lee DYW, Liu J, Zhang S, Huang P, Liu-Chen L. Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. Bioorganic & Medicinal Chemistry Letters. 2017 Mar;27(6):1437–40. doi: 10.1016/j.bmcl.2017.01.090.
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