CAS: 4621-66-3; Pyridine-3-Carbothioamide

该化合物是一种环环生物化合物,其特点是三点方位用木头胺功能组替代了一条环状环,这种结构具有独特的反应性,使其成为有机合成和制药应用中有价值的中间体.它的硫尿素会增强发热特性,有利于协调化学和金属离子结合研究.该化合物在普通有机溶剂中的稳定性和溶性进一步支持其在核脑替代反应和异氧循环衍生中的效用. Pyridine-3-carbothioamide在药用化学中特别与生物活性分子的开发有关,包括潜在的酶抑制剂或抗微生物剂,因为它具有多种功能和功能组的兼容性.

结构式图片

相似化合物

175277-57-3 38824-78-1 1522557-67-0

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合成工艺路线路线简述

  • 合成目标产物 Thionicotinamide 主要起始原料 3-Cyanopyridine
  • (文献来源)合成步骤主要原料 3-Cyanopyridine
3-氰基吡啶置于吡啶,Ammonium Sulfide,三乙胺体系中,用 水 作为反应溶剂,化学反应生成 巯基尼古胺
参考文献:好氧可见光诱导分子间 S-N 键构建:在无光敏剂条件下由硫代酰胺合成 1,2,4-噻二唑
标题:好氧可见光诱导分子间 S-N 键构建:在无光敏剂条件下由硫代酰胺合成 1,2,4-噻二唑
摘要:在无光敏剂的条件下,通过可见光诱导硫代酰胺的氧化环化,开发了一种伴随合成 1,2,4-噻二唑的 S-N 构建的绿色方法.
DOI:10.1002/ejoc.202100440

海关参考信息

专利信息


专利号:EP-4423083-A2
优先权日:2021-11-29
标 题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes
发明人:ÖNAY UÇAR EVREN; DEM RAYAK EREF; BERK BARKIN; YURTTA LEYLA; B LTEK N KALEL SEVDE NUR; AH N ZAFER
权利人:UNIV ISTANBUL MEDIPOL; ISTANBUL UNIV REKTORLUGU; ANADOLU UNIV
摘要:The invention is related to the synthesis of 8 pyrazolone derivative compounds and their activities on COX enzymes.

专利号:US-8895747-B2
优先权日:2009-07-27
标 题 :Method and substances for preparation of N-substituted pyridinium compounds
发明人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL
权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS
摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.

专利号:WO-2023096623-A2
优先权日:2021-11-29
标题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes

专利号:CN-114990587-A
优先权日:2022-06-30
标题:A kind of electrochemical synthesis method of thiazole compounds

专利号:US-8361516-B2
优先权日:2006-08-03
标 题:Composition comprising sarsasapogenin
发明人:LINTNER KARL; MAS CHAMBERLIN CLAIRE
权利人:SEDERMA SA; LINTNER KARL; MAS CHAMBERLIN CLAIRE
摘要:The présent invention relates to a composition comprising sarsasapogenin or a plant extract containing it in order to improve the gêneral state of the skin and in particular to improve and/or embellish any part of the body showing a déficit in lipids. More particularly, the invention is directed to a cosmetic method to improve the figure, comprising the step of topically applying to the skin a cosmetic or dermopharmaceutical composition comprising sarsasapogenin to favour the expansion and/or the formation of the subcutaneous adipose tissue, and/or to favour the lipid synthesis in the epidermis.

专利号:US-RE47415-E
优先权日:2009-02-17
标题:Pyrimidinecarboxamides as CXCR2 modulators
发明人:MAEDA DEAN Y; ZEBALA JOHN A
权利人:SYNTRIX BIOSYSTEMS INC
摘要:There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
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主要参考文献

参考标题:Synthesis And Characterizations Of Novel Thiazolyl-Thiadiazole Derivatives As Telomerase Activators
作者:Kayagil, Ismail,Mutlu, Ayşe Gül,Bayhan, ülkü,Yilmaz, Inanç,Demirayak, şeref
摘要:Pyridine-3/4-Thiocarboxamide Derivatives Were Used As Starting Materials For The Synthesis Of The Target Compounds. The Pyridine-3/4-Thiocarboxamide Derivatives Were Reacted With Ethyl 2-Chloroacetoacetate In Ethanol To Give The Thiazole Derivatives (1, 2). The Two Ethyl Thiazole-Carboxylate Derivatives (1, 2) Thus Obtained Were Treated With Sodium Hydroxide Solution And Ethanol And Converted To Carboxylic Acids (3, 4). The Carboxylic Acid Derivatives (3, 4) Were Reacted With Thiosemicarbazide In Phosphoroxy Trichloride And Aminothiadiazole Rings (5, 6) Were Formed. Thus, Two Thiazolyl-Thiadiazole Amine Derivatives (5, 6) Were Obtained. These Two Derivatives (5, 6) Were Converted Into Two Chloroacetamidothiadiazole Derivatives (7, 8) By Reaction With Chloroacetylchloride Over The Amino Group In The Presence Of Triethylamine In Acetone. After All These Steps, The Starting Materials (7, 8) Needed To Reach The Target Compounds Were Obtained. With The Two Derivatives (7, 8) Obtained In This Last Step, Phenol And Thiophenol Derivatives Were Reacted In Acetone In The Presence Of Potassium Carbonate. The Target Compounds, Thiazolyl-Thiadiazole Derivatives (Tda$_\mathbf1-16}})$, Are Completely Unique And Their Structure Has Been Elucidated By Elemental Analysis, Ir, Nmr, And Ms Spectral Data. After All These Synthesis Steps, Telomerase Activity Studies Were Performed On The Target Compounds Obtained. For This Purpose, A Pcr Elisa-Based Trap Method Was Used On The Heart Of Zebrafish. According To The Enzyme Assay Results, Derivative Tda$_\mathbf8}}$ Has Shown An Increase Of Telomerase Enzyme Activity.

合成参考文献


摘要:Journal of Organic Chemistry., 19(753), 1954
摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382.
摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 339.
摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 343.
摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 361.
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