专利号:EP-4423083-A2 优先权日:2021-11-29 标 题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes 发明人:ÖNAY UÇAR EVREN; DEM RAYAK EREF; BERK BARKIN; YURTTA LEYLA; B LTEK N KALEL SEVDE NUR; AH N ZAFER 权利人:UNIV ISTANBUL MEDIPOL; ISTANBUL UNIV REKTORLUGU; ANADOLU UNIV 摘要:The invention is related to the synthesis of 8 pyrazolone derivative compounds and their activities on COX enzymes.
专利号:US-8895747-B2 优先权日:2009-07-27 标 题 :Method and substances for preparation of N-substituted pyridinium compounds 发明人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL 权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS 摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.
专利号:WO-2023096623-A2 优先权日:2021-11-29 标题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes
专利号:CN-114990587-A 优先权日:2022-06-30 标题:A kind of electrochemical synthesis method of thiazole compounds
专利号:US-RE47415-E 优先权日:2009-02-17 标题:Pyrimidinecarboxamides as CXCR2 modulators 发明人:MAEDA DEAN Y; ZEBALA JOHN A 权利人:SYNTRIX BIOSYSTEMS INC 摘要:There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
参考标题:Synthesis And Characterizations Of Novel Thiazolyl-Thiadiazole Derivatives As Telomerase Activators 作者:Kayagil, Ismail,Mutlu, Ayşe Gül,Bayhan, ülkü,Yilmaz, Inanç,Demirayak, şeref 摘要:Pyridine-3/4-Thiocarboxamide Derivatives Were Used As Starting Materials For The Synthesis Of The Target Compounds. The Pyridine-3/4-Thiocarboxamide Derivatives Were Reacted With Ethyl 2-Chloroacetoacetate In Ethanol To Give The Thiazole Derivatives (1, 2). The Two Ethyl Thiazole-Carboxylate Derivatives (1, 2) Thus Obtained Were Treated With Sodium Hydroxide Solution And Ethanol And Converted To Carboxylic Acids (3, 4). The Carboxylic Acid Derivatives (3, 4) Were Reacted With Thiosemicarbazide In Phosphoroxy Trichloride And Aminothiadiazole Rings (5, 6) Were Formed. Thus, Two Thiazolyl-Thiadiazole Amine Derivatives (5, 6) Were Obtained. These Two Derivatives (5, 6) Were Converted Into Two Chloroacetamidothiadiazole Derivatives (7, 8) By Reaction With Chloroacetylchloride Over The Amino Group In The Presence Of Triethylamine In Acetone. After All These Steps, The Starting Materials (7, 8) Needed To Reach The Target Compounds Were Obtained. With The Two Derivatives (7, 8) Obtained In This Last Step, Phenol And Thiophenol Derivatives Were Reacted In Acetone In The Presence Of Potassium Carbonate. The Target Compounds, Thiazolyl-Thiadiazole Derivatives (Tda$_\mathbf1-16}})$, Are Completely Unique And Their Structure Has Been Elucidated By Elemental Analysis, Ir, Nmr, And Ms Spectral Data. After All These Synthesis Steps, Telomerase Activity Studies Were Performed On The Target Compounds Obtained. For This Purpose, A Pcr Elisa-Based Trap Method Was Used On The Heart Of Zebrafish. According To The Enzyme Assay Results, Derivative Tda$_\mathbf8}}$ Has Shown An Increase Of Telomerase Enzyme Activity.
合成参考文献
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