CAS: 434-43-5; 2-Methyl-3-Phenylbutan-2-Amine
该化合物是一种替代地雷化合物,其组成为苯基组和三级矿体结构,其分子框架将芳香和脂类成分结合在一起,使其成为有机合成和制药研究的多用途中间体.第三级矿物质提高了稳定性,而苯基组则有可能进一步发挥作用.该化合物可能有利于生物活性分子的开发,因为它在结构上与药用活性胺相似.其定义明确的化学特性有利于精确的反应,使之适合医药化学和材料科学的应用.建议适当的处理和储存以保持其完整性.
- 英文名称2-Methyl-3-Phenylbutan-2-Amine
- 中文名称喷托雷司
- 其它别名Phenethylamine,a,a,b-trimethyl- (7CI,8CI); 2-Amino-2-methyl-3-phenylbutane; Pentorex; Phenpentermine; dl-Phenpentermine; a,a,b-Trimethylphenethylamine
- CAS编号434-43-5
- MFCD编号:MFCD01707973
- EINECS号:207-102-6
- FDA UNII编号:K97CJK0FXR
- 分子式:C11H17N分子量:163.26
- 产品CID: 1445324
- 产品分类有机原料 → 苯类化合物 → 苯和取代衍生物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: UMWAUEZOGHNSCH-UHFFFAOYNA-N
- 1S/C11H17N/c1-9(11(2,3)12)10-7-5-4-6-8-10/h4-9H,12H2,1-3H3
- 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数2.0
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜3-甲基丁-2-烯-2-基苯置于10-Phenyl-9-(2,4,6-Trimethylphenyl)Acridinium Tetrafluoroborate,碳酸氢铵,2-氨基苯硫醇体系中,用 二氯甲烷,氯苯 作为反应溶剂,化学反应 12.0H,以71%的收率获得产物喷托雷司
参考文献:通过选择性无金属加氢胺化直接从烯烃中获取伯胺
标题:通过选择性无金属加氢胺化直接从烯烃中获取伯胺
摘要:由容易获得的前体直接和选择性合成伯胺是有吸引力的,但仍具有挑战性.在此,我们报道了室温下通过无金属的区域选择性加氢胺从烯烃快速合成伯胺的方法.碳酸铵首次用作氨替代物,可在温和条件下将末端和内部烯烃有效转化为线性,α支化和α叔伯胺.该方法提供了一种直接而有效的方法,可用于制药化学和其他领域特别感兴趣的各种先进的,高度官能化的伯胺.
DOI:10.1002/anie.202016679
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人：POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
专利号:US-8598153-B2
优先权日:2006-09-22
标题 :Method of treatment using fatty acid synthesis inhibitors
发明人：SINGH SHEO B; TOTA MICHAEL R; WANG JUN
权利人:SINGH SHEO B; TOTA MICHAEL R; WANG JUN; MERCK SHARP & DOHME
摘要:The present invention relates to natural products that possess fatty acid synthesis inhibitor activity and can be used to treat and prevent diseases such as obesity, cancer, diabetes, fungal infections, Mycobacterium tuberculosis infections, malarial infections and other apicomplexan protozoal diseases.
专利号:US-2016340305-A1
优先权日:2014-01-03
标题 :Direct stereospecific synthesis of unprotected aziridines from olefins
专利号:AU-2007300627-A1
优先权日:2006-09-22
标题:Method of treatment using fatty acid synthesis inhibitors
专利号:AU-2007300627-B2
优先权日:2006-09-22
标题 :Method of treatment using fatty acid synthesis inhibitors
专利号:EP-2083831-A2
优先权日:2006-09-22
标题 :Method of treatment using fatty acid synthesis inhibitors
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Therapie., 34(205), 1979 []
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
📝 需求与反馈
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