CAS: 4324-37-2; 2-Methoxypropionic Acid

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23953-00-6 23943-96-6 79-33-4

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CAS号124-41-4 甲醇钠 | CAS号598-72-1 2-溴丙酸 | CAS号27871-49-4 L-乳酸甲酯 | CAS号74-88-4 碘甲烷 | CAS号67-56-1 甲醇 | CAS号547-64-8 乳酸甲酯 | CAS号41918-08-5 S)-(-)-2-甲氧基丙酸乙酯 | CAS号535-11-5 2-溴丙酸乙酯 | CAS号17639-76-8 2-甲氧基丙酸甲酯 | CAS号4324-39-4 O-甲基-L-乳酸乙酯 | CAS号1742-14-9 双二甲苯基乙烷 | CAS号201230-82-2 carbon monoxide | CAS号23953-00-6 (S)-2-甲氧基丙酸 | CAS号17639-76-8 2-甲氧基丙酸甲酯 | CAS号4324-39-4 O-甲基-L-乳酸乙酯 | CAS号530-45-0 1-甲基-4-[1-(4-甲基... | CAS号56680-75-2 2-methoxypropan... | CAS号60359-75-3 2-phenoxyethyl ...

S)-(-)-2-甲氧基丙酸乙酯 以 乙醇 作为反应溶剂,化学反应 3.0H,以92%的收率获得产物2-甲氧基丙酸
参考文献:含有两种不同β-离去基团的烷基自由基的产物研究和激光闪光光解与烯烃阳离子自由基的形成一致
标题:含有两种不同β-离去基团的烷基自由基的产物研究和激光闪光光解与烯烃阳离子自由基的形成一致
摘要:1-溴-2-甲氧基-1-苯基丙-2-基 (3) 和 2-甲氧基-1-苯基-1-二苯基磷酸丙-2-基 (4) 是在混合物中各自 Ptoc 前体的连续光解下反应生成的乙腈和甲醇.自由基在β-位进行取代基的杂裂断裂以产生烯烃阳离子自由基(5).z-2-甲氧基-1-苯基丙烯 (15) 是在 1,4-环己二烯存在下形成的主要产物,据信是由氢原子转移到烯烃阳离子自由基的氧上,然后去质子化的结果.激光闪光光解实验表明 5 和 1,4-环己二烯之间的反应以大约 6 X 10(5) M(-1) S(-1) 的速率常数发生.观测到 2,2-二甲氧基-1-苯基丙烷 (18) 作为次要产物.激光闪光光解实验在 K <1 X 10(3) M(-1) S(-1) 处将甲醇捕获的上限设置为 5,并且不提供除 5 以外的反应性中间体的形成的任何证据.使用两种含有不同离去基团的 Ptoc 前体反应生成一个共同的烯烃阳离子自由基使
DOI:10.1021/ja0042938

专利信息

专利号:US-8748660-B2
优先权日:2012-07-09
标题:Process for the synthesis of antiepileptic drug lacosamide
发明人：MURUGAN MUTHUKRISHNAN; MUJAHID MOHAMMAD; MAJUMDAR PRASHANT PRAMOD
权利人:MURUGAN MUTHUKRISHNAN; MUJAHID MOHAMMAD; MAJUMDAR PRASHANT PRAMOD; COUNCIL SCIENT IND RES
摘要:The present invention relates to the improved and efficient process for the synthesis of antiepileptic drug Lacosamide in high enantiopurity (>98% ee) and better yield. More particularly, the present invention relates to improved and efficient, cost effective process for synthesis of desired (R) isomer of Lacosamide starting from commercially available (S)-benzyl glycidyl ether.

专利号:US-5204456-A
优先权日:1986-04-08
标题:Derivatives of nucleosides and their use for the synthesis of oligonucleotides
发明人：MOLKO DIDIER; SCHULHOF JEAN-CLAUDE; TEOULE ROBERT
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group with R1 representing a hydrogen atom or a alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical R4 represents a hydrogen atom, the radical of formula: or a radical suitable for the synthesis of polynucelotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.

专利号:US-4980460-A
优先权日:1986-04-08
标 题 :Protected nucleosides which permit more efficient oligonucleotide syntheses
发明人：MOLKO DIDIER; SCHULHOF JEAN-CLAUDE; TEOULE ROBERT
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group with R1 representing a hydrogen atom or an alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical R4 represents a hydrogen atom, the radical of formula: or a radical suitable for the synthesis of polynucleotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.

专利号:US-4591370-A
优先权日:1983-01-19
标 题:Cryogenic process for removing acid gases from gas mixtures by means of a solvent
发明人：GAZZI LUIGI; D AMBRA ROBERTO; DI CINTIO ROBERTO; RESCALLI CARLO; VETERE ALESSANDRO
权利人:SNAM PROGETTI
摘要:A process for removing acid gases from natural or synthesis gases by absorption, comprising the following stages: n (a) cooling the natural or synthesis gas to be purified to condense part of the CO 2 contained in said gas; n (b) feeding the cooled and partly condensed gas to an absorption column in order to reduce the acid gas content to the required value; n (c) regenerating the solvent or solvents used in the acid gas absorption, the solvent or solvents used being chosen from esters, alcohols and ethers of low molecular weight.

专利号:US-4561869-A
优先权日:1983-01-19
标题:Cryogenic process for the selective removal of acid gases from gas mixtures by means of a solvent
发明人：GAZZI LUIGI; D AMBRA ROBERTO; DI CINTIO ROBERTO; RESCALLI CARLO; VETERE ALESSANDRO
权利人:SNAM PROGETTI
摘要:A cryogenic process for removing acid gases from natural or synthesis gases, comprising the following stages: n (a) feeding the natural or synthesis gas to a first absorption column in order to absorb the H 2 S; n (b) cooling the substantially H 2 S-free gas to condense part of the CO 2 contained in said gas; n (c) feeding the cooled and partly condensed gas to a second absorption column in order to reduce the CO 2 content to the required value; n (d) regenerating the solvent or solvents used in the acid gas absorption, the solvent or solvents used being chosen from esters, alcohols or ethers, of low molecular weight.

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.