专利号:US-7498434-B2 优先权日:2004-01-14 标题:Two-phase method for the synthesis of selected pyrazolopyrimidines 发明人:CANTRELL GARY LEE; MOSER FRANK WILLIAM; HALVACHS ROBERT EDWARD 权利人:MALLINCKRODT INC 摘要:An improved method of making a substituted pyrazolopyrimidine. The method comprises reacting a aminopyrazole compound or a salt thereof with a substituted 1-oxo-2-propenyl-arene(-heterocycle) or a salt thereof under acidic conditions in a reaction medium including a two-phase mixture of an aqueous solution and a water-immiscible organic liquid. Specific substituted pyrazolopyrimidines include N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide and N-methyl-N-(3-{3-[2-thienyl-carbonyl]-pyrazolo[1,5-a]-pyrimidin-7-yl}phenyl)acetamide.
专利号:US-2025268860-A1 优先权日:2021-10-22 标 题 :Composition for use in the cutaneous synthesis of hyaluronic acid, in an immuno-cutaneous response and to improve skin 发明人:BERNARD PHILIPPE 权利人:JR 摘要:A composition comprising baicalin or a derivative thereof, more particularly in combination with chlorogenic acid or a derivative thereof, as well as the cosmetic use of such a composition and its medical applications.
专利号:US-9051656-B2 优先权日:2009-07-23 标题 :Electrochemical synthesis of aryl-alkyl surfacant precursor 发明人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI 权利人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI; CERAMATEC INC 摘要:An aryl-alkyl (R—Ar) hydrocarbon is prepared by an electrosynthesis process in an electrolytic cell having an alkali ion conductive membrane positioned between an anolyte compartment configured with an anode and a catholyte compartment configured with a cathode. An anolyte solution containing an alkali metal salt of an alkyl carboxylic acid and an aryl compound is introduced into the anolyte compartment. The aryl compound may include an alkali metal salt of an aryl carboxylic acid, an arene (aromatic) hydrocarbon, or an aryl alkali metal adduct (Ar − M + ). The anolyte solution undergoes electrolytic decarboxylation to form an alkyl radical. The alkyl radical reacts with the aryl compound to produce the aryl-alkyl hydrocarbon.
专利号:WO-2023067251-A1 优先权日:2021-10-22 标 题:Composition for use in the cutaneous synthesis of hyaluronic acid, in an immuno-cutaneous response and to improve skin
专利号:US-2014186905-A1 优先权日:2011-08-15 标题 :Biotechnological synthesis process of organic compounds with the aid of an alkl gene product 发明人:SCHAFFER STEFFEN; GIELEN JASMIN; DECKER NICOLE; KIRCHNER NICOLE; HAAS THOMAS; POETTER MARKUS; HAEGER HARALD 权利人:SCHAFFER STEFFEN; GIELEN JASMIN; DECKER NICOLE; KIRCHNER NICOLE; HAAS THOMAS; POETTER MARKUS; HAEGER HARALD; EVONIK DEGUSSA GMBH 摘要:Subject matter of the invention is a biotechnological process for the production of organic compounds with the aid of at least one alkL gene product.
专利号:US-3799958-A 优先权日:1971-07-21 标题 :Ester synthesis for preparation of specific glycerides 发明人:MITCHELL L 权利人:ETHYL CORP 摘要:DIPOLAR APROTIC SOLVENT SUCH AS DIMETHYL SULFOXIDE ARE EFFICACIOUSLY EMPLOYED IN THE REACTION OF ALKALI METAL CARBOXYLATES WITH ORGANIC HALIDES. FOR THE FORMATION OF SPECIFIC TRIGLYCERIDES, GLYCERYL MONO- OR DIHALIDES ARE PREFERABLY EMPLOYED. REACTION SEQUENCES HAVE BEEN DEVISED FOR PREPARATION OF TRIGLYCERIDES WHEREBY UNDESIRABLE ACYL GROUP MIGRATION DOES NOT OCCUR.
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