CAS: 3303-55-7; L-Phenylalanyl-L-Leucine

相似化合物

4313-73-9 79396-84-2 33014-68-5

上下游产品

Pip°C-Phe-Leu L-leucine N-(1-Benzotriazolylcarbonyl)-L-phenylalanin N-tert-butoxycarbonyl-L-phenylalanineN-tert-butoxycarbonyl-L-phenylalanineZ(OMe)-Gly-Phe-Leu-OH N-(3,4,4-trimethyl-1,2-dioxetan-3-ylmethoxycarbonyl)-L-phenylalanyl-L-leucine B°C-Tyr(Bzl)-Gly-Gly-Phe-Leu-OH glycyl-L-phenylalanyl-L-leucine

📜N-[n-[(Phenylmethoxy)Carbonyl]-L-Phenylalanyl]-L-Leucine置于cell Extract Of Sphingomonas Paucimobilis Sc 16113体系中,用 水 作为反应溶剂,化学反应 20.0H,以85%的收率获得产物l-苯丙氨酰-L-亮氨酸
参考文献:N-苄氧羰基的对映选择性酶解
标题:N-苄氧羰基的对映选择性酶解
摘要:已经开发出一种新的酶促方法,用于从受保护的氨基酸和相关化合物中对映选择性地裂解n-苄氧基羰基(cbz)基团.从鲍氏鞘氨醇单胞菌sc 16113的细胞提取物中分离出cbz-脱保护酶,并纯化至同质.纯化的蛋白质的分子量为155,000道尔顿,亚基大小为44,000道尔顿.
DOI:10.1002/adsc.200303038

专利信息

专利号:US-3846399-A
优先权日:1969-04-10
标题:Process for controlled stepwise synthesis of polypeptides
发明人：HIRSCHMANN R; DENKEWALTER R
权利人:MERCK & CO INC
摘要:The invention disclosed herein relates to a novel process for the controlled, stepwise synthesis of polypeptides and proteins. More particularly, it is concerned with a process for the rapid and efficient preparation of polypeptides in which multiple sequential steps are carried out without isolation of intermediate peptides. This process for the controlled stepwise synthesis of polypeptides involves reacting a starting amino acid or peptide (or derivative thereof) with an N-carboxy amino acid anhydride (or derivative thereof) in an aqueous medium under conditions of controlled pH such that the only amino group present in appreciable concentration in reactive form during the course of the reaction is the amino group in the starting amino acid or peptide.

专利号:US-4629784-A
优先权日:1983-08-16
标 题:Synthesis of cyclopropane amino acids
发明人：STAMMER CHARLES H
权利人:UNIV GEORGIA RES FOUND
摘要:Cyclopropane ('Cyclopropyl') amino acids and peptides containing at least one cyclopropyl amino acid are disclosed. The processes for synthesizing cyclopropyl amino acids and peptides containing at least one cyclopropyl amino acid are also disclosed. Cyclopropyl amino acids are useful as enzyme inhibitors and as substitutes for natural amino acids in peptide hormones such as regulators of bodily functions to enhance bioactivity, to stabilize the peptide into which it is incorporated to cleavage by enzymes and to convert such peptides into enzyme inhibitors.

专利号:US-2025197441-A1
优先权日:2023-12-19
标题 :Safety-Catch Linkers for Solid Phase Peptide Synthesis
发明人：ALBERICIO PALOMERA FERNANDO; DE LA TORRE BEATRIZ GARCIA; NOKI SIKABWE; SANEII HOSSAIN
权利人:AAPPTEC LLC
摘要:A safety-catch linker for solid phase peptide synthesis (SPPS) is provided, having a chemical structure according to Formula I:wherein R1 and R2 are each independently selected from hydrogen and methyl; R3 is absent or phenyl; and n is 0 or 1. Also provided are methods of synthesizing the linker, methods of solid phase peptide synthesis (SPPS) of a target peptide employing the resin-bound linker, and kits for SPPS.

专利号:US-2008051323-A1
优先权日:2004-08-21
标 题 :Chloroquine drug compositions and methods for their synthesis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. n The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.

专利号:US-2007060499-A1
优先权日:2005-09-15
标 题 :Chloroquine combination drugs and methods for their synthesis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.

专利号:US-2007166281-A1
优先权日:2004-08-21
标题 :Chloroquine coupled antibodies and other proteins with methods for their synthesis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents such as therapeutic antibodies or insulin, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the drug is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to a drug directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing the drug for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and antibody or insulin to their site of action.