CAS: 24939-24-0; 4-Aminobenzene-1-Sulfonyl Chloride

相似化合物

269747-25-3 19715-49-2 78798-60-4

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CAS号98-74-8 4-硝基苯磺酰氯 | CAS号19837-78-6 N-(4-acetylphen... | CAS号72-14-0 磺胺噻唑 | CAS号127-69-5 磺胺二甲异唑 | CAS号345970-48-1 4-[2-[(4-aminop... | CAS号121-57-3 对氨基苯磺酸 | CAS号21626-70-0 4-(吗啉-4-基磺酰基)苯胺 | CAS号183004-94-6 [(1S,2R)-1-苄基-2... | CAS号169280-56-2 4-氨基-N-[(2R, 3S... | CAS号53668-36-3 4-Amino-N-isobu... | CAS号5450-86-2 Benzenesulfonic...

📜对硝基苯磺酰氯置于氢气体系中,用 Neat (No Solvent) 用作溶剂,95.0 °C,2.0 Mpa 条件下,反应 3.0H,反应生成4-氨基苯-1-磺酰氯
参考文献:二氧化铈负载的钯催化剂对硝基芳烃的无溶剂化学选择性加氢的高性能和活性中心
标题:二氧化铈负载的钯催化剂对硝基芳烃的无溶剂化学选择性加氢的高性能和活性中心
摘要:通过简单的浸渍方法制备的氧化铈负载的钯催化剂(pd / Ceo 2)表现出令人兴奋的催化活性和高化学选择性,可在温和反应下对多种取代的硝基芳烃进行无溶剂加氢反应,包括将可还原的官能团还原为相应的芳族胺条件.以硝基苯为例,在40oc和100oc下,Pd / Ceo 2催化剂的苯胺收率> 99%,周转频率分别高达11 411 H-1和69 824 H-1.Pd 2+离子物种以孤立的单原子形式存在,在pd表面具有-Pd 2+-O 2--Ce 4+-键x Ce 1− X O 2− σ固溶体,被发现是在不存在溶剂的情况下硝基芳烃选择性加氢的活性位点.优异的催化性能可归因于pd 2+离子与ceo 2独特的表面位点之间的协同作用.提出了在pd / Ceo 2上用h 2氢化硝基芳烃的可能机理.Pd / Ceo 2催化剂可以很容易地回收,并且可以重复使用至少七个循环反应而不会损失催化性能.
Doi:10.1002/cctc.201700631

专利信息

专利号:US-10675366-B2
优先权日:2016-08-12
标 题 :Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2
发明人：BEINAT CORRINE GAYE; ALAM ISRAT SHAMIMA; JAMES MICHELLE L; GAMBHIR SANJIV S; SRINIVASAN ANANTH
权利人:UNIV LELAND STANFORD JUNIOR
摘要:The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [18F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.

专利号:US-10246411-B2
优先权日:2014-10-29
标 题:(Z)-3,4,5-trimethoxystyrylbenzenesulfonamides as potential anticancer agents
发明人：KAMAL AHMED; RASALA MAHESH; RATNA REDDY CHALLA; BHARATH KUMAR GAJJELA; SASTRY VISWESWARA; BASHA SHAIK ANVER; SANTHOSH REEDY VANGALA
权利人:COUNCIL SCIENT IND RES
摘要:This present invention relates to (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides of general formula A. The invention also provides the synthesis of (Z)-3,4,5-trimethoxystyrylbenzenesulfonamides useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof.