CAS: 2143917-62-6; N-(6-(1-Methyl-1H-Pyrazol-4-yl)Isoquinolin-3-yl)-2-(4-Methylpiperazin-1-yl)Isonicotinamide
- 英文名称N-(6-(1-Methyl-1H-Pyrazol-4-yl)Isoquinolin-3-yl)-2-(4-Methylpiperazin-1-yl)Isonicotinamide
- 中文名称N-(6-(1-甲基-1H-H-4-基)异喹啉-3-基)-2-(4-甲基哌嗪-1-基)异烟酰胺
- IUPAC名称N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide
- 其它别名4-Pyridinecarboxamide, 2-(4-Methyl-1-Piperazinyl)-N-[6-(1-Methyl-1H-Pyrazol-4-yl)-3-Isoquinolinyl]-; Cirtuvivint; N-(6-(1-Methyl-1H-Pyrazol-4-yl)Isoquinolin-3-yl)-2-(4-Methylpiperazin-1-yl)Isonicotinamide
- CAS编号2143917-62-6
- MFCD编号:MFCD34578253
- FDA UNII编号:7T1PY32ZPH
- 分子式:C24H25N7O分子量:427.51
- 产品CID: 1115124
- 产品分类Protein Tyrosine Kinase/RTK → DYRK | Inhibitors/Agonists → Cell Cycle → CDK
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜N-(6-Bromo-3-Isoquinolyl)-2-(4-Methylpiperazin-1-yl)Pyridine-4-Carboxamide,1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧杂戊硼烷-2-基)-1H-吡唑 在 [1,3-Bis(2,6-Diisopropylphenyl)Imidazol-2-Ylidene](3-Chloropyridyl)Palladium(Ll) Dichloride,Caesium Carbonate体系中,用 1,4-二氧六环,水作为反应溶剂,以52 %的收率获得2-(4-Methylpiperazin-1-yl)-N-[6-(1-Methylpyrazol-4-yl)-3-Isoquinolyl]Pyridine-4-Carboxamide
参考文献:Comparative Efficacy And Selectivity Of Pharmacological Inhibitors Of Dyrk And Clk Protein Kinases
标题:Comparative Efficacy And Selectivity Of Pharmacological Inhibitors Of Dyrk And Clk Protein Kinases
摘要:
Doi:10.1021/Acs.Jmedchem.2C02068
海关参考信息
- 2902200000-苯
2912110000-甲醛
2921211000-乙二胺
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/acs.jmedchem.1c00985
摘要:Qin Z, Qin L, Feng X, Li Z, Bian J. Development of Cdc2-like Kinase 2 Inhibitors: Achievements and Future Directions. J Med Chem. 2021 Sep 23;64(18):13191–211. doi: 10.1021/acs.jmedchem.1c00985.
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