CAS: 19875-04-8; 2-Methylpyrimidin-4(3H)-One

结构式图片

相似化合物

1034827-34-3 944905-88-8 1935338-85-4

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号5941-55-9 3-乙氧基丙烯酸乙酯 | CAS号124-42-5 乙脒盐酸盐 | CAS号7314-67-2 4-isopropoxy-2-... | CAS号106690-58-8 5,8-Methano-2-m... | CAS号34780-29-5 3-氧代丙酸乙酯 | CAS号111079-41-5 5-碘-2-甲基-4(3H)-嘧啶酮 | CAS号111079-17-5 4-氯-5-碘-2-甲基-嘧啶 | CAS号4994-86-9 4-氯-2-甲基嘧啶 | CAS号27058-54-4 4-羟基-2-甲基嘧啶-5-甲腈 | CAS号698-29-3 2-甲基-4-氨基嘧啶-5-腈 | CAS号17758-38-2 2,3-Dimethylpyr... | CAS号7314-65-0 4-甲氧基-2-甲基嘧啶 | CAS号1676-57-9 5-溴-2-甲基嘧啶-4-醇 | CAS号56844-01-0 2-甲基噻吩并[2,3-d]嘧啶

合成工艺路线路线简述

    📜4-Methyl-3,5-Diazatricyclo[6.2.1.02,7]Undeca-3,9-Dien-6-One 以82%的收率获得
    参考文献:Stajer G.; Szabo E.; Bernath G.; Sohar P.,Magy. Kem. Folyoirat,92,(1986) N 5,234-236
    标题:Stajer G.; Szabo E.; Bernath G.; Sohar P.,Magy. Kem. Folyoirat,92,(1986) N 5,234-236

    专利信息


    专利号:US-2024239799-A1
    优先权日:2021-04-02
    标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
    发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
    权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
    摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

    专利号:CN-120518668-A
    优先权日:2025-05-19
    标题:Synthesis method of diazinon

    专利号:CN-119684131-A
    优先权日:2024-12-10
    标题:Continuous synthesis method of ultrasonic reinforced FOX-7

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Synthesis Of Novel C-2 Substituted Pyrimidine Nucleoside Analogs
    作者:Martin Dunkel,P. Dan Cook,Oscar L. Acevedo |发布日期:1993.10
    摘要:A Series Of 2-(2-Oxoalkylidene)-4(1H)-Pyrimidinone Nucleoside Analogs Were Synthesized By The Addition Of The Lithium Enolates Of Methylketones To 2,5′- And 2,2′-Anhydrouridines And To 2,5′-Anhydrothymidines. Alternatively, 2-Thiouridine Was Alkylated With Bromomethyl Ketones To Yield 2-(2-Oxoalkyl)Thio-4(1H)-Pyrimidinone Ribofuranosides In Good Yields. These Intermediates Were Subsequently Transformed

    合成参考文献


    参考文献:10.1007/bf00850093
    摘要:Zav'yalov SI, Gunar VI, Martirosyan ZA, Ovechkina LF. Synthesis of cytosine derivatives from 1-substituted uracils. Russian Chemical Bulletin. 1972 Nov;21(11):2458–61. doi: 10.1007/bf00850093.
    参考文献:10.1007/bf01184892
    摘要:Prikazchikova LP, Rybchenko LI, Klyuchko SV, Pirozhenko VV, Drach BS. Amidoalkylation of 2- and 4-hydroxy-pyrimidines with N-(1,2,2,2-tetra-chloroethyl)amides of carboxylic acids. Chemistry of Heterocyclic Compounds. 1994 Oct;30(10):1235–9. doi: 10.1007/bf01184892.
    参考文献:10.1007/bf00755293|10.1007/bf00755294
    摘要:Serzhanina VA, Khromov-Borisov NV, Karlinskaya RS. Syntheses and reactions of pyrimidine derivatives. Chemistry of Heterocyclic Compounds. 1968 May;4(3):390–2. doi: 10.1007/bf00755294.
    参考文献:10.1007/bf01031784
    摘要:Chkhikvadze KA, Koretskaya NI, Rodnyanskaya NS, Magidson OY. 5-Substituted pyrimidine derivatives. Chemistry of Heterocyclic Compounds. 1969 Jan;5(1):108–11. doi: 10.1007/bf01031784.
    参考文献:10.1134/s1070363208020205
    摘要:Erkin AV, Krutikov VI. Modified synthesis of some 1-(pyrimidin-2-yl)-3-methyl-4-arylidenepyrazol-5(4H)-ones. Russian Journal of General Chemistry. 2008 Feb;78(2):301–4. doi: 10.1134/s1070363208020205.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知