CAS: 1753-48-6; 2-Aminopyrimidine-5-Carbonitrile

相似化合物

120747-84-4 3167-50-8 50840-23-8

上下游产品

CAS号594-14-9 硫酸胍 | CAS号91-22-5 喹啉 | CAS号7752-82-1 2-氨基-5-溴嘧啶 | CAS号544-92-3 氰化亚铜 | CAS号1753-50-0 2-氯-5-氰基嘧啶

(2E)-3-(二甲基氨基)-2-甲酰基丙烯腈,硫酸亚氨脲置于sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 5.0H,以64%的收率获得2-氨基嘧啶-5-腈
参考文献:Synthesis With Nitriles: 92. Synthesis Of 5-Formylcytosine Derivatives
标题:Synthesis With Nitriles: 92. Synthesis Of 5-Formylcytosine Derivatives
摘要:The Reactivity Of 3-Dimethylamino-2-Formylpropenenitrile (1) With Various Amino Compounds Is Studied. Thus,Condensation Of 1 With Anilines Gives The Corresponding Azomethines (2A-C). Reaction Of 1 With Thiourea And Guanidne Resp.,Leads To 5-Formylthiocytosine (3) And 2-Amino-5-Cyanopyrimidine (4). The 2-Formyl-3-Ureidopropenenitriles (5A-I) Can Be Obtained By Reaction Of 1 With Urea And Substituted Ureas. 5A-I Can Easily Be Cyclized To 3-Substituted 5-Formylcytosines (6-E). Condensation Of 6 With Aniline,Benzylamine And Phenylhydrazine Leads To The Azomethines (7A-I). Pyrido [ 2,3-D ] Pyrimidine-6-Carbonitriles (8A,8B,Sd And 83) Are Obtained By Reaction Of 6 With Malononitrile.
Doi:10.3987/com-93-6416

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.