CAS: 1708-29-8; 2,5-Dihydrofuran

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Erythritol置于dioxo-(Pyridine-2,6-Dicarboxylato)(Hexamethylphosphoramide)Molybdenum(Vi),三苯基膦体系中,用 甲苯 用作溶剂,以16 %的收率获得2,5-二氢呋喃
参考文献:Mo(Vi) Dioxo(Pyridine-2,6-Dicarboxylato) 络合物催化多元醇脱氧脱水的机理研究
标题:Mo(Vi) Dioxo(Pyridine-2,6-Dicarboxylato) 络合物催化多元醇脱氧脱水的机理研究
摘要:对可再生资源替代石化原料的需求引起了极大的兴趣.脱氧脱水 (Dodh) 将生物质衍生的多元醇和二醇还原为烯烃和二烯,可能使烯烃生产更接近碳中性来源.我们通过二氧代-Mo(Vi) 催化剂 Moo 2 (Pyridine-2,6-Dicarboxylato)(Hmpa) 报告了许多芳香族,脂肪族和生物质模型二醇的 Dodh.使用 Pph 3和 1-苯基-1,2-乙二醇发现了最佳反应条件,苯乙烯产量高达 93%.使用原位红外光谱的机理研究支持双指数动力学机制,其中决速步骤的速率常数为 ∼5 x 10-5 S-1. Dft 计算支持动力学研究,并表明最大的动力学势垒是在二醇形成过程中质子从底物转移到金属-氧代键.
Doi:10.1021/acs.Organomet.3C00001

专利信息

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:WO-2025053792-A1
优先权日:2023-09-06
标题:Collective synthesis of phantomolin family through total synthesis of the sesquiterpene lactone molephantin
发明人：CHIBA SHUNSUKE; PATOURET REMI HENRI LOUIS; LI HOI YEUNG; LAI SOAK KUAN
权利人:UNIV NANYANG TECH
摘要:Disclosed herein are processes to generate an intermediate in the total synthesis of (+)- molephantin or a derivative thereof, and a total synthesis of (+)-molephantin or a derivative thereof. Also disclosed herein are methods of forming a compound of formula XIV and of forming a compound of formula XV, wherein compound of formula XIV and compound of formula XV are as defined in the description.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-6924385-B2
优先权日:2002-11-18
标 题:Method for synthesis of aliphatic isocyanates from aromatic isocyanates
发明人：LETTMANN CHRISTIAN; KOHLSTRUK STEPHAN; STOCHNIOL GUIDO; SPYROU EMMANOUIL
权利人:DEGUSSA
摘要:The invention relates to a method for synthesis of aliphatic isocyanates from aromatic isocyanates in substantially 3 stages. In particular, the invention relates to a method for synthesis of bis{4-isocyanatocyclohexyl}methane (H 12 MDI) from bis{4-isocyanatophenyl}methane (MDI). More especially, the invention relates to a method for synthesis of H 12 MDI with a trans-trans isomer content of <30%, preferably of <20%, particularly preferably of 5 to 15%.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.