CAS: 1596-67-4; L-Thyronine

相似化合物

1034-10-2 1213135-25-1 1354485-04-3

上下游产品

CAS号51-48-9 左旋甲状腺素 | CAS号1041-01-6 3,5-二碘-L-甲状腺素 | CAS号3483-82-7 N-苯甲酰-L-酪氨酸乙酯 | CAS号53663-23-3 1,2,3-三碘-5-硝基苯 | CAS号949-67-7 L-酪氨酸乙酯

甲状腺素置于sodium Tetrahydroborate,C10H8Ste,1,4-二巯基-2,3-丁二醇体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 0.5H,反应生成L-甲状腺氨酸
参考文献:硫属元素取代对甲状腺激素脱碘酶模拟物的显著作用
标题:硫属元素取代对甲状腺激素脱碘酶模拟物的显著作用
摘要:碘甲状腺素脱碘酶是通过催化甲状腺素(t4)的区域选择性脱碘作用来调节甲状腺激素稳态的硒酶.合成的脱碘酶模拟物不仅对于了解酶催化的机理很重要,而且对于开发治疗剂也很重要,因为甲状腺激素水平异常会影响不同疾病的发生,例如缺氧,心肌梗塞,危重疾病,神经元缺血,组织损伤和癌症.本文描述的是,通过碲置换一系列脱碘酶模拟物中的硫/硒原子显着改变了对t4的反应性和区域选择性.
Doi:10.1002/anie.201502762

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:WO-2024200180-A1
优先权日:2023-03-29
标题 :Novel l-thyroxine radioiodine label and process for production thereof
发明人：DREWES BIRTE; BIER DIRK; HOLSCHBACH MARCUS; HUMPERT SWEN; SCHNEIDER DANIELA; NEUMAIER BERND
权利人:FORSCHUNGSZENTRUM JUELICH GMBH
摘要:The present invention relates to a multistage synthesis process proceeding from 3,5-diiodo-L-thyronine for synthesis of an L-thyroxine radiolabelled in the 3 position on the inner ring. The present invention further relates to specific intermediates in the synthesis process of the invention, to the radiolabels obtainable and to the use of the radiolabels in nuclear-medical imaging methods and in in vitro and ex vivo applications.

专利号:US-8183409-B2
优先权日:2004-05-06
标题:High yield and rapid synthesis methods for producing metallo-organic salts
发明人：CHRISTGAU STEPHAN; ANDERSEN JENS E T
权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T; OSTEOLOGIX AS
摘要:A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.