专利号:US-11926589-B2 优先权日:2019-07-09 标 题 :Process for the synthesis of non-racemic cyclohexenes 发明人:REISMAN SARAH; ROMBOLA MICHAEL; LADD CAROLYN L; MCLAUGHLIN MARTIN JOHN; ZUEND STEPHAN; GOETZ ROLAND 权利人:BASF CORP; CALIFORNIA INST OF TECHN 摘要:This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a′ , R 10b′ , R 10c′ , R 10d′ , Z and Z′ have the meanings as defined in the description.
专利号:US-3947517-A 优先权日:1969-06-12 标题:Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines 发明人:MUXFELDT HANS H; MICHAEL JEFFREY 权利人:RESEARCH CORP 摘要:In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this critical hydroxy group is disclosed. Additionally, synthetic procedures for obtaining tetracycline precursors are discussed.
专利号:US-10385010-B1 优先权日:2018-03-28 标 题 :Expedient synthesis of oseltamivir and related compounds via direct olefin diazidation-diamidation reaction 发明人:XU HAO; LI HONGZE; SHEN SHOUJIE; ZHU CHENGLIANG 权利人:UNIV GEORGIA STATE RES FOUND 摘要:Disclosed herein are improved methods for the preparation of oseltamivir, and intermediates useful thereto.
专利号:US-4460507-A 优先权日:1980-10-10 标题:Process for the preparation of thienamycin 发明人:SHIH DAVID H 权利人:MERCK & CO INC 摘要:Disclosed is a process for the total synthesis of thienamycin from descysteaminylthienamycin 1 ##STR1## via thienamycin sulfoxide 4: ##STR2## R 3 , R°, R' are blocking groups.
专利号:US-2006286379-A1 优先权日:2002-08-13 标题 :Magnetic nanoparticle supports 发明人:GAO YONG 权利人:GAO YONG 摘要:Coated magnetic nanoparticles and their compositions used for labeling, detecting, sorting, and isolating biological, organic and inorganic molecules, and for medical therapies, and as a platform for organic, biological and physical transformations. An oxidation approach for fabricating iron oxide nanoparticles, methods for the synthesis of magnetic compositions comprising a magnetic core associated with a functional molecule or molecular complexes, and methods for the synthesis of water-soluble magnetic particles/compositions.
专利号:US-2023331690-A1 优先权日:2020-11-01 标 题 :Thc derivatives, oral dosage forms comprising same, uses thereof for treating diseases and disorders and synthesis thereof 发明人:ALBECK AMNON; WOLFMAN JACOB; EYAL NADAV 权利人:UNIV BAR ILAN; EYBNA TECH LTD 摘要:Provided herein are THC derivatives, formulations thereof, synthesis thereof and uses thereof through oral administration, for treatment of diseases and disorders.