CAS: 14719-37-0; Ethyl 2-((Tert-Butoxycarbonyl)Amino)Acetate

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2-(Di-Tert-Butoxycarbonylamino)Acetic Acid Ethyl Ester置于bismuth(III) Bromide,水体系中,用 乙腈 用作溶剂,化学反应 2.0H,以82%的收率获得n-Boc-甘氨酸乙酯
参考文献:Efficient And Selective Cleavage Of The T-Butoxycarbonyl Group From Di-T-Butylimidodicarbonate Using Catalytic Bismuth(III) Bromide In Acetonitrile
标题:Efficient And Selective Cleavage Of The T-Butoxycarbonyl Group From Di-T-Butylimidodicarbonate Using Catalytic Bismuth(III) Bromide In Acetonitrile
摘要:Di-T-Butylimidodicarbonates Can Be Chemoselectively And Efficiently Deprotected To The Corresponding Mono-Boc-Protected Amines In High Yields Using A Catalytic Amount Of Bismuth(III) Bromide In Acetonitrile At Room Temperature. This Method Is Mild And Compatible With The Presence Of A Wide Range Of Functional And Other Protecting Groups In The Substrates,Such As Tbdms,Mom And Mono-Boc Or Cbz-Protected Amines,Etc. The Method Has Advantages Of Ease Of Operation And Use Of Nontoxic And Inexpensive Catalyst. (C) 2009 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetlet.2009.06.104